EUKHeist stramenopile MAG analysis
Sarah K Hu
11/24/2020
1 Introduction
MAGs clustered as Dictyochophyceae or putative stramenopiles isolated as a case study to demonstrate how we can use metatranscriptomic data to explore the ecological niches of stramenopiles. Putative stramenopile MAGs were assigned to the broader SAR group (Stramenopiles, Alveolata, and Rhizaria) based on MMSeqs and EUKulele (see Figure 2), but one phylogenetically similar clade was chosen to represent putative heterotrophic stramenopiles likely related to Dictyochophyceae. Core questions to address:
(1) What is the biogeography of these MAGs with respect to region, depth, and size fraction? (2) How does the distribution of MAGs related to predicted trophic mode? (3) What are the core ecological differences among these taxa? (4) Are the currently SAR-assigned MAGs related to the more heterotrophic Dictyochophyceae species?
2 Set up R environment & import data
library(tidyverse); library(broom); library(ggtext); library(directlabels)
library(ggupset); library(cowplot); library(pheatmap)3 Tara Ocean metadata
Import and clean metadata for all MAGs.
metaT_metadata <- read.delim("../data/SampleList_2020_metaT.txt")
metaG_metadata <- read.delim("../data/SampleList_2020_metaG.txt")
# Import Lat & Long
tmp_metadata <- read.delim("/Users/sarahhu/Desktop/Projects/eukheist_proj/dictyochophyceae-analysis/input-data/PRJEB4352_metaG_wenv.txt")# Separate ERRs into rows & keep only what I need
metaG_reformat <- metaG_metadata %>%
separate_rows(ERR_list, sep = ", ") %>%
separate(Sub_region, c("REGION", "subregion"), sep = "-", remove = FALSE) %>%
separate(Depth_sizefrac, c("DEPTH", "min", "max"), sep = "-", remove = FALSE) %>%
unite(SIZEFRAC, min, max, sep = "-") %>%
select(-Assembly_group, -ERR_count, run_accession = "ERR_list", REGION, DEPTH, SIZEFRAC) %>%
left_join(tmp_metadata %>% select(run_accession, sampleid = Sample.material, Longitude, Latitude, Station)) %>%
distinct()4 Import list of MAGs of interest
24 MAGs selected by membership to Dictyochophyceae and closely related heterotroph-predicted stramenopile clade.
mags_tmp <- read.delim("../data/mags-of-interest-24.txt", header = FALSE)
mags_of_interest <- as.character(mags_tmp$V1);mags_of_interest## [1] "TOPAZ_SAS1_E003" "TOPAZ_MSS1_E028" "TOPAZ_IOS1_E045" "TOPAZ_MSS1_E004"
## [5] "TOPAZ_SAS1_E036" "TOPAZ_SPS1_E066" "TOPAZ_SAS1_E034" "TOPAZ_SPS1_E018"
## [9] "TOPAZ_SPS1_E054" "TOPAZ_MSS1_E011" "TOPAZ_NPS1_E005" "TOPAZ_NAS1_E036"
## [13] "TOPAZ_NAX1_E011" "TOPAZ_MSS1_E023" "TOPAZ_NPS1_E025" "TOPAZ_SPS1_E074"
## [17] "TOPAZ_SPS1_E030" "TOPAZ_MSD1_E003" "TOPAZ_MSS1_E026" "TOPAZ_NAS1_E023"
## [21] "TOPAZ_SAD1_E033" "TOPAZ_SPD1_E019" "TOPAZ_SPS1_E070" "TOPAZ_SAS1_E035"n = 13 from SAR n = 11 are dictyochophyte MAGs (derived from EUKulele & MMSeqs taxonomy assignment)
Import MAG files, including a name schematic key for the MAG TOPAZ-based naming. Also add the estimated taxonomy assignments.
mag_counts_updated <- read.csv("/Users/sarahhu/Desktop/Projects/eukheist_proj/dictyochophyceae-analysis/input-data/MAG_tpm.csv")
mag_rename_key <- read.delim("/Users/sarahhu/Desktop/Projects/eukheist_proj/dictyochophyceae-analysis/input-data/renamed-eukaryotic-mags.tsv", sep = "\t")
# Import MAG taxonomic assignments (Feb 2, 2021)
mag_taxonomy <- read.csv("/Users/sarahhu/Desktop/Projects/eukheist_proj/dictyochophyceae-analysis/input-data/2021-marzoanmmetsp-estimated-taxonomy-levels.csv")
# head(mag_taxonomy)Import list of MAGs with EUKulele taxonomy assignment at lower threshold (n=33); this way it includes more MAGs with dictyochophyte assignments. Incorporate BUSCO completeness and contamination to pare down the list.
euk_thres <- read.delim("/Users/sarahhu/Desktop/Projects/eukheist_proj/dictyochophyceae-analysis/input-data/list_dictyochophyceae.txt", header = FALSE)
buscos <- read.csv("/Users/sarahhu/Desktop/Projects/eukheist_proj/dictyochophyceae-analysis/input-data/EUK_BUSCO_CC.csv")Isolate TPM MAG abundances.
mag_tpm <- mag_counts_updated %>%
left_join(mag_rename_key, by = c("Genome" = "old_mag_name")) %>%
filter(new_mag_name %in% mags_of_interest) %>%
pivot_longer(cols = starts_with("ERR"), names_to = "run_accession", values_to = "tpm") %>%
left_join(metaG_reformat) %>%
select(mag = new_mag_name, -Genome, everything()) %>%
data.frame## Joining, by = "run_accession"# head(mag_tpm)
# length(unique(mag_tpm$mag))5 MAG relative abundance by location
Sum TPM of MAGs based on Size Fraction, Location, and Depth
mag_tpm_location <- mag_tpm %>%
filter(!is.na(REGION)) %>%
group_by(mag, DEPTH, REGION, SIZEFRAC) %>%
summarise(mag_tpm = sum(tpm)) %>%
mutate(log_mag_tpm = log(mag_tpm)) %>%
unite(SAMPLE, REGION, DEPTH, SIZEFRAC, sep = " ", remove = FALSE) %>%
filter(!is.na(mag_tpm))## `summarise()` has grouped output by 'mag', 'DEPTH', 'REGION'. You can override using the `.groups` argument.# head(mag_tpm_location)
hist(mag_tpm_location$log_mag_tpm)
Save output R objects as data checkpoints to add to available repo.
# save(mag_tpm_location, mag_tpm, file = "../data/MAG-casestudy-Stramenopile-2021.RData")5.1 Generate heatmap of MAG relative abundance by location (SI)
Load existing data from R objects.
load("../data/MAG-casestudy-Stramenopile-2021.RData", verbose = TRUE)## Loading objects:
## mag_tpm_location
## mag_tpmVisualize MAGs with pheatmap
pheat_mags <- mag_tpm_location %>%
select(mag, SAMPLE, log_mag_tpm) %>%
filter(!is.na(log_mag_tpm)) %>%
mutate_if(is.numeric, function(x) ifelse(is.infinite(x), 0, x)) %>%
pivot_wider(id_cols = SAMPLE, names_from = mag, values_from = log_mag_tpm, values_fill = 0) %>%
column_to_rownames(var = "SAMPLE")## Adding missing grouping variables: `DEPTH`, `REGION`## `mutate_if()` ignored the following grouping variables:
## Columns `mag`, `DEPTH`, `REGION`# Obtain annotation
annotate_mags <- mag_tpm_location %>%
ungroup() %>%
filter(!is.na(REGION)) %>%
select(SAMPLE, REGION, DEPTH, SIZEFRAC) %>%
distinct() %>%
column_to_rownames(var = "SAMPLE")
rownames(annotate_mags) <- rownames(pheat_mags)
# Specify color schema
annotation_colors = list(
REGION = c(IO= "#711518", MS= "#ce536b", NAO= "#c76b4a", NPO= "#dfa837", SAO= "#93b778", SO= "#61ac86", SPO= "#657abb", RS= "#67765b"),
DEPTH = c(DCM= "#74a9cf", FSW= "#969696", SRF= "#d0d1e6", MIX= "#0570b0", MES= "#023858", ZZZ= "#252525"),
SIZEFRAC = c(`0.8-5.00` = "#f7fcb9",`180-2000.00` = "#004529", `20-180.00` = "#41ab5d",`5-20.00` = "#addd8e"))MAG relative abundace by sample and TPM.
# pdf("../si-figures/SI-SAR-Dictyocho-MAG-MAG-relabun-bysample.pdf", h = 16, w = 15)
pheatmap(pheat_mags,
annotation_row = annotate_mags,
annotation_colors = annotation_colors,
scale = "none",
cluster_cols = TRUE,
cluster_rows = TRUE,
clustering_method = "average",
cellwidth = 10, cellheight = 10,
main = "MAG Relative Abundance (TPM)")
# dev.off()6 Biogeography of MAGs
Plot MAGs based on global distribution - TPM.
library(rworldmap)## Loading required package: sp## ### Welcome to rworldmap ##### For a short introduction type : vignette('rworldmap')Figure out latitute and longitude
mag_tpm_tmp <- mag_tpm %>%
mutate(lat_1 = round(Latitude, digits = 1),
long_1 = round(Longitude, digits = 1),
lat_2 = round(Latitude, digits = 2),
lat_3 = round(Latitude, digits = 3),
long_2 = round(Longitude, digits = 2),
long_3 = round(Longitude, digits = 3))
# length(unique(mag_tpm_tmp$lat_1))
# length(unique(mag_tpm_tmp$long_1))Make summary data frame by latitute and longitude.
mag_tpm_map <- mag_tpm_tmp %>%
filter(tpm > 0) %>%
filter(!is.na(REGION)) %>%
group_by(mag, DEPTH, REGION, SIZEFRAC, lat_1, long_1) %>%
summarise(mag_tpm_latlong = sum(tpm)) %>%
mutate(log_mag_tpm = log(mag_tpm_latlong)) %>%
unite(SAMPLE, REGION, DEPTH, SIZEFRAC, sep = " ", remove = FALSE) %>%
filter(!is.na(mag_tpm_latlong)) %>%
mutate(Location = paste(lat_1, long_1))## `summarise()` has grouped output by 'mag', 'DEPTH', 'REGION', 'SIZEFRAC', 'lat_1'. You can override using the `.groups` argument.Get background world map
map_get_world <- function(resolution="coarse"){
worldMap <- rworldmap::getMap(resolution = resolution) # Change to "coarse" for global maps / "low" for regional maps
world.points <- fortify(worldMap)
world.points$region <- world.points$id
world.df <- world.points[,c("long","lat","group", "region")]
}
map_world <- function(color_continents = "#969696", color_borders = "#969696", resolution = "coarse") {
world.df <- map_get_world(resolution)
map <- ggplot() +
geom_polygon(data = world.df, aes(x=long, y = lat, group = group), fill=color_continents, color=color_borders) +
# scale_fill_manual(values= color_continents , guide = FALSE) +
scale_x_continuous(breaks = (-4:4) * 45) +
scale_y_continuous(breaks = (-2:2) * 30) +
xlab("Longitude") + ylab("Latitude") +
coord_fixed(1.3) +
theme_bw()
# species_map <- species_map + coord_map () # Mercator projection
# species_map <- species_map + coord_map("gilbert") # Nice for the poles
return(map)
}Factor for depths for the map.
depth_order <- c("DCM", "FSW", "SRF", "MIX", "MES", "ZZZ")
depth_color <- c("#74a9cf", "#969696", "#d0d1e6", "#0570b0", "#023858", "#252525")
mag_tpm_map$DEPTH_ORDER <- factor(mag_tpm_map$DEPTH, levels = depth_order)
#
mag_order <- c("TOPAZ_MSS1_E028","TOPAZ_SAS1_E003","TOPAZ_NAX1_E011","TOPAZ_IOS1_E045","TOPAZ_SAS1_E036","TOPAZ_NAS1_E036","TOPAZ_MSS1_E004","TOPAZ_SAD1_E033","TOPAZ_MSS1_E023","TOPAZ_NPS1_E025","TOPAZ_MSS1_E011","TOPAZ_NPS1_E005","TOPAZ_SPS1_E018","TOPAZ_SPS1_E054","TOPAZ_MSD1_E003","TOPAZ_MSS1_E026","TOPAZ_SAS1_E035","TOPAZ_NAS1_E023","TOPAZ_SPS1_E030","TOPAZ_SPS1_E074","TOPAZ_SPD1_E019","TOPAZ_SPS1_E070","TOPAZ_SAS1_E034","TOPAZ_SPS1_E066")
mag_tpm_map$MAG_ORDER <- factor(mag_tpm_map$mag, levels = mag_order)# pdf("../si-figures/SI-stramenopile-MAG-map.pdf", w=17,h=20)
map_world() +
geom_jitter(data = mag_tpm_map,
aes(x = long_1, y = lat_1,
fill = DEPTH_ORDER,
size = mag_tpm_latlong),
shape = 21, color = "black") +
scale_size_continuous(range = c(1,14)) +
scale_fill_manual(values = depth_color) +
facet_wrap(MAG_ORDER ~ ., ncol = 4) +
theme(strip.background = element_blank(),
strip.text = element_text(face = "bold", size = 14, hjust = 1, vjust = 1),
axis.text = element_text(size = 10, hjust = 1, vjust = 1),
legend.title = element_blank())## Regions defined for each Polygons## Warning: Removed 24 rows containing missing values (geom_point).
# dev.off()7 Investigate metatranscriptome reads mapped to MAGs
Import the results from metatranscriptome mapping onto putative dictyochophyte and SAR group MAGs. Explore trophic roles and shared/unique functional profiles.
7.1 Import and compile raw metatranscriptome mapping information
For loop to determine summed transcript counts that hit the 11 core putative dictyochophyte MAGs.
# For loop to import all data and compile
summed_counts <- list.files(path = "/Users/sarahhu/Desktop/Projects/eukheist_proj/dictyochophyceae-analysis/input-data",pattern = "tpm.summedcounts")
# summed_counts
# rm(imported)
# rm(compiled_metaT_hits)
for (a in summed_counts) {
imported <- read.csv(paste("/Users/sarahhu/Desktop/Projects/eukheist_proj/dictyochophyceae-analysis/input-data/", a, sep = ""))
names <- unlist(strsplit(a,".tpm.summedcounts"))
imported$MAG <- names[1]
if (!exists("compiled_metaT_hits")) {
compiled_metaT_hits <- imported
} else {
compiled_metaT_hits <- rbind(compiled_metaT_hits, imported)
}
rm(imported)
}# Rename MAGs with TOPAZ name schematic
metaT_mapped <- compiled_metaT_hits %>%
left_join(mag_rename_key, by = c("MAG" = "old_mag_name")) %>%
select(-MAG) %>%
select(MAG = new_mag_name, everything()) %>%
data.frame
# head(metaT_mapped)Checkpoint for saving the metatranscriptome data with TOPAZ naming schematic.
# save(metaT_mapped, mag_rename_key, file = "../data/MAG-casestudy-Stramenopile-metaT-2021.RData")7.2 Analysis of KEGG identities among MAGs and predicted trophic mode
Match KEGG identities to kegg module information and curated list of kegg pathways of interest.
Import metatranscriptome data from MAGs of interest.
load("../data/MAG-casestudy-Stramenopile-metaT-2021.RData", verbose=T)## Loading objects:
## metaT_mapped
## mag_rename_keytrophy <- read.csv("../data/trophy_data.csv")
# head(mag_rename_key)
# head(trophy)
trophy_refine <- trophy %>%
left_join(mag_rename_key, by = c("MAGs" ="old_mag_name")) %>%
select(-MAGs)
mag_order## [1] "TOPAZ_MSS1_E028" "TOPAZ_SAS1_E003" "TOPAZ_NAX1_E011" "TOPAZ_IOS1_E045"
## [5] "TOPAZ_SAS1_E036" "TOPAZ_NAS1_E036" "TOPAZ_MSS1_E004" "TOPAZ_SAD1_E033"
## [9] "TOPAZ_MSS1_E023" "TOPAZ_NPS1_E025" "TOPAZ_MSS1_E011" "TOPAZ_NPS1_E005"
## [13] "TOPAZ_SPS1_E018" "TOPAZ_SPS1_E054" "TOPAZ_MSD1_E003" "TOPAZ_MSS1_E026"
## [17] "TOPAZ_SAS1_E035" "TOPAZ_NAS1_E023" "TOPAZ_SPS1_E030" "TOPAZ_SPS1_E074"
## [21] "TOPAZ_SPD1_E019" "TOPAZ_SPS1_E070" "TOPAZ_SAS1_E034" "TOPAZ_SPS1_E066"# write_delim(filter(trophy_refine, new_mag_name %in% mag_order) %>% distinct(), path = "trophy-24mags.txt", delim = "\t")metaT_mapped_trophy <- metaT_mapped %>%
left_join(trophy_refine, by = c("MAG" = "new_mag_name"))
# Get list of phototrophy predicted MAGs
tmp <- metaT_mapped_trophy %>%
filter(PredictedTrophicMode == "Phototroph")
photo_mags <- as.character(unique(tmp$MAG))
# length(photo_mags)7.2.1 Dendrogram of MAGs
MAG_dendro_binary <- metaT_mapped %>%
select(MAG, KO) %>%
add_column(BIN = 1) %>%
pivot_wider(names_from = "KO", values_from = BIN, values_fill = 0) %>%
column_to_rownames(var = "MAG") %>%
data.frame
head(MAG_dendro_binary)## K00003 K00010 K00012 K00014 K00021 K00022 K00026 K00029 K00033
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E023 1 0 0 0 1 1 0 1 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K00036 K00052 K00053 K00057 K00059 K00064 K00077 K00078 K00088
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 1 1 1 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 0 0 1 1 1 1 1
## TOPAZ_MSS1_E023 1 0 1 0 1 0 1 1 1
## TOPAZ_MSS1_E026 1 0 1 0 1 1 1 1 1
## K00108 K00111 K00121 K00128 K00133 K00134 K00135 K00140 K00145
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 0 1 1 0 1 0 1 1
## K00147 K00161 K00164 K00166 K00167 K00208 K00215 K00218 K00219
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 0 0 0
## TOPAZ_MSS1_E004 0 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 0 1 1 0 1 0 1 1
## TOPAZ_MSS1_E023 0 1 1 1 1 1 0 0 0
## TOPAZ_MSS1_E026 0 1 1 0 1 1 0 0 0
## K00222 K00225 K00228 K00231 K00232 K00234 K00235 K00237 K00239
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 0 0
## TOPAZ_MSS1_E011 0 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E023 0 0 1 0 1 0 1 0 0
## TOPAZ_MSS1_E026 1 1 0 0 1 1 1 1 1
## K00240 K00248 K00249 K00252 K00255 K00266 K00278 K00281 K00286
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 1 1 0 0 1 0 1 1
## TOPAZ_MSS1_E023 1 0 1 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K00287 K00297 K00311 K00318 K00323 K00324 K00326 K00327 K00338
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 0 0 0 1 1 0
## TOPAZ_MSS1_E011 1 0 0 1 1 1 1 0 1
## TOPAZ_MSS1_E023 0 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K00344 K00364 K00382 K00383 K00384 K00387 K00389 K00392 K00411
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 1 0 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 0 1
## K00413 K00419 K00432 K00451 K00452 K00453 K00459 K00463 K00472
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 0 1
## TOPAZ_MSS1_E011 0 0 1 1 0 0 1 0 1
## TOPAZ_MSS1_E023 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 0 1
## K00477 K00485 K00486 K00500 K00507 K00514 K00521 K00522 K00525
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 1 0 1
## TOPAZ_MSS1_E004 0 1 0 1 0 1 1 0 1
## TOPAZ_MSS1_E011 1 0 1 0 0 1 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 1 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 0 0
## K00526 K00528 K00537 K00547 K00548 K00555 K00556 K00558 K00559
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 0 0 0 1 1 1 1
## TOPAZ_MSS1_E023 0 0 0 1 1 0 1 0 1
## TOPAZ_MSS1_E026 0 1 0 1 1 1 1 1 1
## K00560 K00564 K00565 K00568 K00573 K00586 K00587 K00588 K00600
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 0 1 0 0 1 1
## TOPAZ_MSS1_E011 1 0 1 0 1 0 0 1 1
## TOPAZ_MSS1_E023 0 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 0 1 1 1
## K00602 K00605 K00606 K00609 K00615 K00620 K00626 K00630 K00640
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 1 1 1 0 0
## TOPAZ_MSS1_E004 1 1 1 0 0 1 1 0 1
## TOPAZ_MSS1_E011 0 0 1 0 1 0 1 1 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 0 1 0 1 1 1 0 0
## K00641 K00645 K00648 K00654 K00655 K00658 K00670 K00671 K00679
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 1 1 1 0
## TOPAZ_MSS1_E004 0 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E023 1 0 0 0 1 0 0 1 0
## TOPAZ_MSS1_E026 1 0 0 1 1 0 1 1 0
## K00681 K00699 K00717 K00721 K00726 K00729 K00731 K00737 K00750
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 0 1 0 0
## TOPAZ_MSS1_E011 1 0 0 0 0 1 1 1 0
## TOPAZ_MSS1_E023 1 0 1 1 0 1 0 1 0
## TOPAZ_MSS1_E026 1 0 1 1 0 1 1 1 0
## K00762 K00764 K00765 K00766 K00767 K00768 K00773 K00784 K00787
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 1 0 0 1 1 0
## TOPAZ_MSS1_E011 0 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E023 1 0 1 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K00789 K00791 K00793 K00797 K00798 K00799 K00804 K00809 K00814
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K00815 K00816 K00817 K00819 K00820 K00825 K00826 K00831 K00837
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 1 1 0 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 1 1 0 1 1
## TOPAZ_MSS1_E023 0 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K00849 K00852 K00855 K00856 K00857 K00858 K00859 K00863 K00864
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E023 1 1 0 0 1 1 0 0 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K00869 K00872 K00873 K00875 K00876 K00889 K00891 K00895 K00901
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 1 0 0 1
## TOPAZ_MSS1_E023 0 0 1 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 0 1 1
## K00902 K00914 K00921 K00927 K00928 K00930 K00939 K00940 K00942
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E004 0 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 0 1 1 1 0 1 0 1
## TOPAZ_MSS1_E023 0 0 1 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 0 1 1 1
## K00943 K00948 K00958 K00962 K00963 K00972 K00981 K00988 K00991
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 0 1 0 0
## TOPAZ_MSS1_E004 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 1 0 1 1 0 1 1 0
## TOPAZ_MSS1_E023 1 1 0 0 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 0 0 1 1 1 0 0
## K00995 K01001 K01008 K01027 K01046 K01054 K01057 K01061 K01062
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 0 1 1 1 0
## TOPAZ_MSS1_E004 0 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 0 0 0 1 1 1 1
## TOPAZ_MSS1_E023 0 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 0 1 1 1 0 1 1 1 0
## K01069 K01070 K01071 K01074 K01076 K01079 K01087 K01091 K01092
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 0 1 1 0 0 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K01094 K01099 K01101 K01102 K01112 K01113 K01115 K01127 K01135
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 0 0 0 0 1 1 1 0 1
## TOPAZ_MSS1_E026 0 1 0 0 1 1 1 1 1
## K01136 K01137 K01142 K01148 K01153 K01158 K01164 K01176 K01180
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E004 1 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E011 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E023 1 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 0 0
## K01181 K01183 K01186 K01187 K01192 K01194 K01201 K01205 K01206
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 1 0 1 0 0 1 1 0
## TOPAZ_MSS1_E023 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K01210 K01225 K01227 K01228 K01235 K01239 K01243 K01247 K01251
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E004 1 1 1 0 1 1 1 0 1
## TOPAZ_MSS1_E011 1 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E023 0 1 0 0 1 1 1 0 0
## TOPAZ_MSS1_E026 0 1 1 1 1 1 0 1 0
## K01254 K01255 K01256 K01259 K01262 K01265 K01267 K01273 K01279
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 0 1 0 1
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 0 1
## K01280 K01288 K01299 K01301 K01303 K01304 K01307 K01309 K01322
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 0 0 1 1 0 0 1
## TOPAZ_MSS1_E011 1 0 1 1 1 1 1 1 0
## TOPAZ_MSS1_E023 1 0 0 0 1 0 1 1 1
## TOPAZ_MSS1_E026 1 0 0 1 1 0 1 1 1
## K01338 K01354 K01358 K01363 K01366 K01392 K01408 K01409 K01412
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 0 1 1 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 0 1 1 1 0 0
## TOPAZ_MSS1_E023 0 1 0 0 0 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 0
## K01414 K01424 K01426 K01427 K01443 K01448 K01456 K01462 K01468
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 0 1 0
## TOPAZ_MSS1_E004 0 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 0 1 1 1
## TOPAZ_MSS1_E023 0 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 0
## K01473 K01476 K01477 K01480 K01487 K01488 K01489 K01490 K01491
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 0 1 1 1 1 0 1
## TOPAZ_MSS1_E023 0 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E026 0 0 1 0 0 1 1 1 1
## K01493 K01497 K01507 K01517 K01519 K01520 K01525 K01527 K01529
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 1 0 0 1 1
## TOPAZ_MSS1_E004 0 1 1 1 0 1 1 1 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E023 0 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E026 0 0 1 1 1 0 0 1 0
## K01530 K01535 K01537 K01539 K01551 K01555 K01556 K01557 K01578
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 1 0 1 1 1 0 1
## TOPAZ_MSS1_E026 1 1 0 0 1 1 1 0 1
## K01586 K01588 K01589 K01591 K01595 K01598 K01599 K01610 K01611
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E023 1 0 0 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K01620 K01623 K01624 K01625 K01626 K01634 K01639 K01640 K01641
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 0 1 0 1 1 0 0 1
## TOPAZ_MSS1_E023 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 0 1 1 1 1 1
## K01647 K01661 K01662 K01663 K01676 K01679 K01682 K01687 K01689
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 0 1 0 1 1 1
## TOPAZ_MSS1_E011 1 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E023 0 0 0 1 1 1 0 1 1
## TOPAZ_MSS1_E026 1 0 0 0 1 1 1 1 1
## K01692 K01694 K01695 K01696 K01697 K01702 K01703 K01704 K01710
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 0 1 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 1 0 0 0 1
## TOPAZ_MSS1_E011 0 1 1 1 0 0 1 0 1
## TOPAZ_MSS1_E023 1 0 1 0 1 0 0 0 0
## TOPAZ_MSS1_E026 1 0 0 0 1 0 0 0 0
## K01712 K01714 K01719 K01724 K01726 K01733 K01735 K01736 K01737
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 0 1 1 1 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 0 1 1
## K01738 K01740 K01745 K01749 K01754 K01755 K01756 K01759 K01760
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K01764 K01772 K01775 K01783 K01784 K01785 K01792 K01800 K01802
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E023 1 1 0 0 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 0 0 1 1 1 1 0
## K01803 K01807 K01809 K01810 K01823 K01834 K01835 K01845 K01847
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 0 1 1 1
## TOPAZ_MSS1_E004 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 0 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K01855 K01858 K01866 K01867 K01868 K01869 K01870 K01872 K01873
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E023 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K01874 K01875 K01876 K01880 K01881 K01883 K01885 K01886 K01887
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K01889 K01890 K01892 K01893 K01895 K01897 K01899 K01900 K01902
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 1 0 1 0 1 1 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K01903 K01904 K01908 K01915 K01918 K01919 K01922 K01923 K01930
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 0 0 0 0 1 1 0 1 0
## TOPAZ_MSS1_E023 0 1 0 1 0 0 0 1 1
## TOPAZ_MSS1_E026 0 1 0 1 1 0 1 1 1
## K01933 K01934 K01937 K01938 K01939 K01945 K01950 K01951 K01952
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E011 1 0 0 1 1 1 1 1 0
## TOPAZ_MSS1_E023 0 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K01953 K01956 K01958 K01965 K01968 K01969 K01972 K01990 K01992
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E011 1 0 0 1 0 0 1 1 1
## TOPAZ_MSS1_E023 1 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K02016 K02040 K02066 K02067 K02069 K02109 K02111 K02113 K02115
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 0 1 1 0 1 0
## TOPAZ_MSS1_E004 0 1 0 0 1 0 1 0 1
## TOPAZ_MSS1_E011 1 0 0 0 1 1 0 1 0
## TOPAZ_MSS1_E023 0 1 0 0 1 1 0 1 0
## TOPAZ_MSS1_E026 1 1 0 0 1 1 0 1 0
## K02134 K02135 K02137 K02138 K02144 K02145 K02146 K02147 K02148
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 1 1 0 0 0 1 1 0
## TOPAZ_MSS1_E023 0 0 1 1 0 1 0 0 1
## TOPAZ_MSS1_E026 1 0 1 0 1 0 1 1 1
## K02149 K02150 K02151 K02154 K02155 K02180 K02183 K02201 K02209
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 0 1 1 0 0 1 0 1
## TOPAZ_MSS1_E023 1 0 0 1 1 0 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K02210 K02212 K02214 K02218 K02219 K02221 K02234 K02257 K02258
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 0 1 1 0 1
## TOPAZ_MSS1_E011 1 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 0 0 0 1 0 1
## TOPAZ_MSS1_E026 1 1 0 0 1 0 1 0 1
## K02259 K02260 K02267 K02291 K02293 K02295 K02316 K02320 K02321
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 0 1 0 1 1
## TOPAZ_MSS1_E004 1 0 1 0 1 0 0 1 1
## TOPAZ_MSS1_E011 1 0 0 1 1 0 0 1 0
## TOPAZ_MSS1_E023 1 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E026 1 0 1 0 0 1 0 1 1
## K02324 K02325 K02327 K02328 K02331 K02350 K02355 K02356 K02358
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E011 1 0 0 1 1 1 1 0 0
## TOPAZ_MSS1_E023 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 0 1
## K02365 K02377 K02409 K02410 K02433 K02469 K02501 K02503 K02516
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 0 0 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 1 0 1 1
## TOPAZ_MSS1_E011 1 0 0 0 0 0 1 1 0
## TOPAZ_MSS1_E023 0 1 0 0 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 0 0 0 0 0 1 0
## K02519 K02520 K02528 K02540 K02541 K02542 K02551 K02564 K02604
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 0 0 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 1 0 1 1 0 1 0 0
## TOPAZ_MSS1_E023 1 1 0 1 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 0 1 1
## K02606 K02608 K02636 K02638 K02641 K02684 K02685 K02687 K02696
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 0 1 1 0 0
## TOPAZ_MSS1_E004 1 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E011 0 0 1 1 1 1 0 1 0
## TOPAZ_MSS1_E023 1 0 0 0 0 1 1 0 0
## TOPAZ_MSS1_E026 1 1 0 0 0 1 1 0 0
## K02714 K02716 K02717 K02719 K02726 K02728 K02732 K02735 K02736
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 0 0 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 0 0 0 1 1 1
## TOPAZ_MSS1_E011 0 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E023 0 0 0 0 0 1 1 0 1
## TOPAZ_MSS1_E026 0 0 0 0 1 1 0 1 0
## K02737 K02738 K02834 K02835 K02836 K02838 K02857 K02860 K02863
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 0 0 0 0 1
## TOPAZ_MSS1_E004 1 0 0 0 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 0 0 0 0 1 1 1
## TOPAZ_MSS1_E023 0 1 0 1 0 1 0 0 1
## TOPAZ_MSS1_E026 0 1 0 0 0 1 0 0 1
## K02864 K02865 K02868 K02870 K02872 K02873 K02875 K02876 K02877
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 1 0 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 1 0 1 0 1 0 1 0
## TOPAZ_MSS1_E023 0 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 0 0 1 0 1 0 1 1 1
## K02884 K02885 K02887 K02888 K02889 K02893 K02894 K02895 K02896
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 0 1 0 0 1
## TOPAZ_MSS1_E011 0 1 0 0 1 0 0 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 0 1 1
## K02901 K02902 K02903 K02905 K02912 K02914 K02915 K02917 K02918
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 0 0 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 1 0 0 1 1
## TOPAZ_MSS1_E011 0 1 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 0 1 1 1
## K02920 K02921 K02923 K02925 K02926 K02927 K02929 K02930 K02934
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E004 0 0 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 1 0 1 1 0 0 1 1 1
## TOPAZ_MSS1_E023 0 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E026 1 0 0 0 1 0 1 0 1
## K02935 K02936 K02937 K02939 K02941 K02943 K02945 K02951 K02953
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 0 0 0
## TOPAZ_MSS1_E004 1 0 1 0 1 0 1 1 1
## TOPAZ_MSS1_E011 0 0 0 0 0 0 1 0 1
## TOPAZ_MSS1_E023 0 0 0 1 0 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 0
## K02956 K02959 K02960 K02962 K02963 K02969 K02975 K02978 K02979
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E004 0 1 0 0 1 0 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 0 1 0 0 1
## TOPAZ_MSS1_E023 0 1 0 1 0 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 0 1 0 1 1
## K02981 K02983 K02984 K02985 K02987 K02988 K02989 K02991 K02995
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 0 0 0 0 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E026 1 0 0 1 1 1 1 1 0
## K02996 K02997 K02999 K03002 K03004 K03006 K03010 K03011 K03013
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 1 0 1 0 1 0 0 0
## TOPAZ_MSS1_E023 1 0 1 0 0 0 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 1 0
## K03014 K03016 K03018 K03019 K03020 K03022 K03023 K03025 K03026
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 0 1 1 0 0
## TOPAZ_MSS1_E011 0 0 0 0 1 0 1 0 0
## TOPAZ_MSS1_E023 1 1 0 1 0 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K03027 K03028 K03029 K03030 K03031 K03032 K03033 K03035 K03036
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 1 0 0 0 0 1 0 0
## TOPAZ_MSS1_E023 0 1 0 0 0 1 1 1 0
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 0 1
## K03037 K03038 K03039 K03061 K03062 K03063 K03070 K03094 K03097
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 0 0 0 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 0 1 1 1 1 1 0 0
## TOPAZ_MSS1_E023 1 1 0 1 1 1 0 1 0
## TOPAZ_MSS1_E026 0 0 1 0 0 1 0 1 1
## K03100 K03105 K03106 K03107 K03108 K03110 K03115 K03128 K03130
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 0 1 0 1
## TOPAZ_MSS1_E004 1 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 0 0 1 1 1 0 0
## TOPAZ_MSS1_E023 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 1 1 0 1 0 1 0 1
## K03131 K03132 K03134 K03135 K03141 K03142 K03143 K03145 K03155
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 0 1 0 1 0
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 1 1 1 1 0 1 0 1
## TOPAZ_MSS1_E023 1 0 0 1 0 1 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 0 1 0
## K03163 K03164 K03165 K03167 K03168 K03177 K03178 K03179 K03183
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 1 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 0 0
## TOPAZ_MSS1_E011 1 1 1 0 1 1 1 0 0
## TOPAZ_MSS1_E023 1 1 1 0 0 0 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 0 0 1 1 0
## K03189 K03190 K03215 K03216 K03217 K03233 K03235 K03236 K03237
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E004 0 0 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E023 0 1 1 0 1 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 0
## K03239 K03242 K03243 K03246 K03247 K03248 K03249 K03250 K03251
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E023 0 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K03252 K03253 K03254 K03256 K03257 K03259 K03260 K03262 K03263
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 1 0 1 0 1
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K03264 K03265 K03267 K03283 K03284 K03301 K03313 K03320 K03321
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 0 1 0 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 0 1 1 1 1
## TOPAZ_MSS1_E023 0 1 0 0 0 1 0 1 0
## TOPAZ_MSS1_E026 1 1 1 0 0 1 0 1 0
## K03327 K03341 K03347 K03349 K03350 K03351 K03352 K03353 K03354
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 1 0 0 1 1 1 1 0
## TOPAZ_MSS1_E023 1 0 1 1 0 1 1 1 0
## TOPAZ_MSS1_E026 1 0 1 1 0 1 1 1 1
## K03355 K03357 K03359 K03363 K03372 K03377 K03386 K03403 K03404
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 0 0 0
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E023 0 0 0 0 1 1 0 0 0
## TOPAZ_MSS1_E026 1 0 0 1 1 1 0 0 0
## K03424 K03426 K03428 K03438 K03439 K03453 K03455 K03456 K03462
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 0 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 1 1 1 0 0 1 1 0
## TOPAZ_MSS1_E023 1 0 0 1 1 0 0 1 0
## TOPAZ_MSS1_E026 1 1 0 1 1 0 0 1 1
## K03469 K03470 K03495 K03501 K03504 K03509 K03511 K03515 K03517
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 0 0 1 1 1 0
## TOPAZ_MSS1_E004 0 0 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 1 1 0 1 0 1 1 0 0
## TOPAZ_MSS1_E023 1 0 1 0 1 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 0 0 1 1 0 0
## K03521 K03526 K03527 K03531 K03538 K03544 K03545 K03564 K03574
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 0 1 1 1 0 0 1
## TOPAZ_MSS1_E004 1 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E011 0 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E023 0 0 0 1 1 1 0 0 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 0 0 1
## K03575 K03593 K03595 K03609 K03626 K03627 K03635 K03637 K03644
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 1 0 0 1
## TOPAZ_MSS1_E023 0 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K03648 K03650 K03657 K03660 K03661 K03665 K03667 K03671 K03676
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 1 0 1 0 1 1
## TOPAZ_MSS1_E023 1 0 1 1 1 0 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 0 0 1 1 1
## K03685 K03686 K03687 K03695 K03699 K03702 K03703 K03704 K03715
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E026 0 1 1 0 0 0 0 1 0
## K03723 K03750 K03768 K03782 K03783 K03790 K03797 K03809 K03833
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 0 0 1 1 1 1
## TOPAZ_MSS1_E011 0 0 1 1 0 1 1 1 0
## TOPAZ_MSS1_E023 0 1 0 1 1 0 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 0 1 0 1 1
## K03839 K03841 K03842 K03843 K03844 K03846 K03847 K03848 K03849
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 1 1 0 0 1
## TOPAZ_MSS1_E011 1 1 0 1 1 0 1 0 1
## TOPAZ_MSS1_E023 0 0 1 1 0 0 0 1 0
## TOPAZ_MSS1_E026 0 1 1 0 1 1 1 1 1
## K03850 K03857 K03861 K03868 K03869 K03871 K03885 K03924 K03941
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 1 0 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 1 1 0 1 0
## TOPAZ_MSS1_E011 0 0 1 0 1 0 1 0 1
## TOPAZ_MSS1_E023 1 0 1 0 1 0 1 0 0
## TOPAZ_MSS1_E026 0 1 1 1 1 0 1 1 1
## K03942 K03943 K03946 K03949 K03950 K03952 K03966 K03977 K03978
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 0 1 0 0
## TOPAZ_MSS1_E004 0 1 0 1 0 1 0 1 1
## TOPAZ_MSS1_E011 0 0 0 0 0 1 0 1 1
## TOPAZ_MSS1_E023 0 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K03979 K04043 K04075 K04077 K04078 K04079 K04082 K04083 K04097
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 1 1 0 0
## TOPAZ_MSS1_E004 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 0 1 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 0 0 0 1 1 1 0 0
## K04348 K04354 K04392 K04437 K04460 K04482 K04487 K04498 K04499
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 0 0 0 1 1 1
## TOPAZ_MSS1_E011 1 0 0 0 1 0 1 1 0
## TOPAZ_MSS1_E023 1 0 0 0 1 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K04507 K04508 K04518 K04523 K04532 K04554 K04564 K04565 K04567
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E023 0 1 0 0 0 1 1 0 0
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K04638 K04646 K04649 K04712 K04718 K04739 K04744 K04774 K04794
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 0 0 1
## TOPAZ_MSS1_E004 1 1 0 0 0 1 0 1 1
## TOPAZ_MSS1_E011 1 0 0 1 0 1 0 1 0
## TOPAZ_MSS1_E023 1 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 0 0 1
## K04797 K04798 K04799 K05019 K05236 K05283 K05284 K05286 K05287
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 1 0 1
## TOPAZ_MSS1_E004 1 0 0 1 1 1 0 1 0
## TOPAZ_MSS1_E011 0 0 1 0 0 1 0 0 1
## TOPAZ_MSS1_E023 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K05290 K05292 K05293 K05294 K05305 K05307 K05309 K05349 K05355
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 0 0 1 0 1 1 1 0
## TOPAZ_MSS1_E023 1 1 0 0 0 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 0
## K05359 K05389 K05396 K05520 K05527 K05535 K05539 K05542 K05543
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 0 1 1 0 1 1
## TOPAZ_MSS1_E004 0 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 0 0 1 1
## TOPAZ_MSS1_E023 0 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E026 0 1 0 0 1 1 0 1 1
## K05546 K05610 K05658 K05749 K05750 K05752 K05755 K05756 K05757
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E004 0 0 1 1 1 0 0 0 1
## TOPAZ_MSS1_E011 0 1 1 1 0 0 1 0 0
## TOPAZ_MSS1_E023 0 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K05758 K05765 K05770 K05794 K05805 K05808 K05838 K05841 K05849
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 0 0 1 1
## TOPAZ_MSS1_E011 0 0 1 0 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 0 0 1 1 1
## K05863 K05906 K05928 K05931 K05941 K05954 K05955 K05956 K05970
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E004 0 1 1 0 0 0 0 1 0
## TOPAZ_MSS1_E011 1 1 0 1 0 1 0 0 0
## TOPAZ_MSS1_E023 1 0 1 0 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 0 1 1
## K05989 K05991 K05995 K06013 K06020 K06027 K06041 K06047 K06062
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 0 0 1
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 0
## K06063 K06066 K06067 K06072 K06100 K06118 K06119 K06133 K06134
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E004 1 0 0 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 0 1 0 0 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 0 1 1
## K06158 K06168 K06171 K06173 K06174 K06176 K06177 K06180 K06184
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E023 1 0 1 1 0 1 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 0 1
## K06185 K06199 K06201 K06207 K06213 K06215 K06219 K06228 K06268
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 0 1 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E023 1 1 0 1 1 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 0 1 1
## K06269 K06287 K06316 K06442 K06443 K06445 K06580 K06628 K06636
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 0 0 1 1 1
## TOPAZ_MSS1_E004 1 0 0 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 1 1 1 1 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 0 0 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 0 0 0 1 1 1
## K06639 K06640 K06642 K06662 K06669 K06671 K06672 K06674 K06675
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 0 0 0 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K06676 K06677 K06678 K06682 K06688 K06689 K06691 K06692 K06693
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E011 1 0 1 0 0 1 0 1 0
## TOPAZ_MSS1_E023 0 1 0 0 1 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 0 0 1
## K06695 K06699 K06861 K06867 K06874 K06877 K06889 K06891 K06901
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E004 0 0 0 1 1 1 1 1 0
## TOPAZ_MSS1_E011 0 0 0 1 1 0 0 1 1
## TOPAZ_MSS1_E023 0 1 0 1 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 0 1 0 1 1 0 1
## K06911 K06925 K06929 K06934 K06940 K06941 K06942 K06943 K06944
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E011 1 0 0 1 0 1 0 0 0
## TOPAZ_MSS1_E023 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K06947 K06961 K06962 K06972 K06974 K06978 K06981 K06989 K06990
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 1 0 0 1 0 1 1 0
## TOPAZ_MSS1_E011 1 1 0 1 1 1 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 0
## K06997 K06999 K07002 K07018 K07023 K07029 K07040 K07050 K07052
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 1 1 0 1 0 0 1 1
## TOPAZ_MSS1_E023 1 1 0 1 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 0 1 1
## K07055 K07090 K07101 K07112 K07126 K07127 K07146 K07151 K07152
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E011 0 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E023 0 1 0 0 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K07160 K07178 K07179 K07195 K07198 K07200 K07203 K07204 K07222
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 0 0 1 1 0
## TOPAZ_MSS1_E004 0 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E011 1 1 1 1 0 0 1 1 0
## TOPAZ_MSS1_E023 0 1 1 0 0 1 1 1 0
## TOPAZ_MSS1_E026 0 1 1 1 0 1 1 1 0
## K07232 K07238 K07240 K07241 K07252 K07253 K07263 K07297 K07304
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 1 0 0 0 1
## TOPAZ_MSS1_E011 1 0 1 1 1 0 0 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 0 0 1 0 1 1 1
## K07313 K07374 K07375 K07390 K07401 K07407 K07432 K07441 K07442
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 0 1 0 1 0 1 1 1 0
## TOPAZ_MSS1_E023 0 0 0 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 0 0 1 0 1 1 1 1
## K07443 K07456 K07466 K07497 K07508 K07509 K07512 K07513 K07542
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 1 1
## TOPAZ_MSS1_E023 0 0 1 0 1 0 1 1 0
## TOPAZ_MSS1_E026 0 0 1 0 0 1 1 1 1
## K07555 K07556 K07560 K07561 K07562 K07565 K07566 K07568 K07573
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 0 0 0 1 0 1 0 1
## TOPAZ_MSS1_E011 0 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E023 1 1 1 1 1 0 1 0 0
## TOPAZ_MSS1_E026 0 1 0 1 1 0 1 1 1
## K07575 K07579 K07583 K07588 K07735 K07739 K07755 K07759 K07766
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E004 0 1 0 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E023 1 0 0 1 1 1 0 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K07767 K07870 K07874 K07889 K07890 K07893 K07897 K07904 K07915
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 0 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E011 1 1 0 1 0 1 1 0 1
## TOPAZ_MSS1_E023 0 1 0 0 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 0 0 1
## K07935 K07937 K07939 K07942 K07943 K07944 K07951 K07953 K07955
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 0 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 0 0 0 1 0 1 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 1 0 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 1 1 1
## K07975 K08054 K08059 K08065 K08066 K08073 K08080 K08081 K08106
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 1 1 0 1 0
## TOPAZ_MSS1_E004 0 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E023 0 0 1 0 0 1 0 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 0
## K08150 K08239 K08246 K08266 K08267 K08272 K08281 K08288 K08316
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 0 1 0
## TOPAZ_MSS1_E004 0 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 1 0 0 0 1 1
## TOPAZ_MSS1_E023 1 1 1 0 1 1 0 1 0
## TOPAZ_MSS1_E026 1 0 0 1 1 1 0 1 0
## K08331 K08332 K08333 K08334 K08337 K08342 K08486 K08489 K08490
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E023 0 1 1 0 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K08492 K08493 K08495 K08496 K08506 K08515 K08516 K08568 K08576
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 0 0 0 1
## TOPAZ_MSS1_E011 1 0 1 0 1 1 0 1 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K08582 K08653 K08658 K08659 K08678 K08679 K08681 K08734 K08735
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E011 1 0 0 1 0 0 0 0 1
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K08736 K08737 K08741 K08744 K08824 K08825 K08827 K08829 K08830
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E023 0 1 0 1 0 0 0 0 0
## TOPAZ_MSS1_E026 0 1 1 0 1 0 1 1 1
## K08832 K08835 K08856 K08866 K08867 K08869 K08870 K08874 K08876
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 0 1 1 1 1 0 0
## TOPAZ_MSS1_E023 1 0 1 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 0 1
## K08880 K08900 K08903 K08906 K08955 K08956 K08963 K08991 K08994
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 1 0 0 0 0 1 0 1
## TOPAZ_MSS1_E023 1 1 0 0 0 0 1 0 1
## TOPAZ_MSS1_E026 1 1 0 0 1 1 1 1 1
## K08997 K08998 K09008 K09009 K09015 K09022 K09117 K09122 K09140
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 0 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 0 1 0 0 1 0 0 1
## TOPAZ_MSS1_E026 1 0 1 1 0 1 0 1 1
## K09142 K09272 K09291 K09313 K09391 K09422 K09458 K09459 K09480
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 0 1
## TOPAZ_MSS1_E011 0 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E023 1 1 0 1 0 1 0 1 0
## TOPAZ_MSS1_E026 0 1 1 1 1 1 0 0 0
## K09481 K09486 K09488 K09490 K09494 K09495 K09496 K09498 K09499
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 0 1
## TOPAZ_MSS1_E011 1 0 1 0 0 0 1 1 1
## TOPAZ_MSS1_E023 0 0 1 0 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K09500 K09506 K09518 K09522 K09523 K09527 K09528 K09533 K09537
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 1 0 0 0 1 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 0
## K09540 K09549 K09553 K09554 K09560 K09566 K09568 K09578 K09595
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 0 1 0 0 1
## TOPAZ_MSS1_E011 1 1 1 0 0 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 0 1 0 1 1 1
## K09611 K09613 K09647 K09649 K09651 K09660 K09667 K09680 K09699
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E023 0 0 1 1 1 1 1 1 0
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 1 1
## K09702 K09704 K09716 K09761 K09780 K09828 K09838 K09839 K09858
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 0 1 0 1 0
## TOPAZ_MSS1_E004 0 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 0 0 1 0 0 0
## TOPAZ_MSS1_E026 1 1 0 0 1 1 0 1 0
## K09861 K09880 K10134 K10203 K10206 K10251 K10268 K10277 K10300
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 0 0 1 1 0
## TOPAZ_MSS1_E004 0 0 1 1 0 0 0 1 1
## TOPAZ_MSS1_E011 0 1 1 1 1 1 0 0 0
## TOPAZ_MSS1_E023 1 0 0 1 0 0 1 1 0
## TOPAZ_MSS1_E026 1 0 0 0 0 1 1 1 0
## K10353 K10355 K10356 K10364 K10389 K10393 K10396 K10397 K10398
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 1 1 1 0 0 0
## TOPAZ_MSS1_E011 1 0 1 0 0 1 0 1 1
## TOPAZ_MSS1_E023 1 0 0 0 0 0 1 1 1
## TOPAZ_MSS1_E026 1 0 0 1 0 1 0 1 0
## K10401 K10405 K10406 K10408 K10409 K10410 K10411 K10413 K10414
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 1 1 1 0 1 0 0 0
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 0 0
## TOPAZ_MSS1_E026 0 0 0 1 1 1 1 1 1
## K10415 K10417 K10418 K10419 K10420 K10523 K10532 K10536 K10563
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 0 1
## K10573 K10575 K10576 K10577 K10581 K10587 K10592 K10598 K10601
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 0 0 1 0 1
## TOPAZ_MSS1_E004 0 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 1 0 0 0
## TOPAZ_MSS1_E023 1 1 0 0 1 0 1 0 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 1 0 1
## K10610 K10627 K10640 K10643 K10661 K10669 K10685 K10686 K10688
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E004 0 0 1 0 1 1 1 1 0
## TOPAZ_MSS1_E011 1 0 1 0 1 1 1 0 0
## TOPAZ_MSS1_E023 1 0 1 1 1 1 0 1 0
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 0 0
## K10689 K10691 K10696 K10703 K10704 K10727 K10730 K10732 K10733
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 0 0 1 0 0 0 0
## TOPAZ_MSS1_E011 1 0 1 1 0 1 0 0 1
## TOPAZ_MSS1_E023 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 0 1 1
## K10734 K10736 K10738 K10739 K10740 K10745 K10746 K10747 K10751
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 0 1 0 1 0 1 1 1
## TOPAZ_MSS1_E011 0 1 1 0 0 1 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 0 1 0 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 0
## K10753 K10754 K10756 K10758 K10767 K10768 K10769 K10770 K10773
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 1 1 0 0 0 0 0 1
## TOPAZ_MSS1_E023 0 0 1 1 1 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 0 0 1 1 1 1
## K10798 K10807 K10837 K10839 K10843 K10844 K10846 K10848 K10858
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 0 1 1 0 1 1 0
## TOPAZ_MSS1_E023 1 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 1 1 1
## K10862 K10863 K10865 K10866 K10869 K10870 K10873 K10875 K10878
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 0 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 0 0 0 1 1 0 1 0
## TOPAZ_MSS1_E023 0 0 1 1 1 1 0 0 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 0 1 1
## K10879 K10881 K10884 K10885 K10891 K10895 K10901 K10903 K10908
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 0 0 1 0 0 1 0
## TOPAZ_MSS1_E023 0 1 1 1 1 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K10949 K10956 K10960 K10990 K10994 K11000 K11068 K11086 K11087
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 0 1 0 1
## TOPAZ_MSS1_E004 1 1 0 0 1 1 0 1 0
## TOPAZ_MSS1_E011 0 1 1 0 1 1 0 0 0
## TOPAZ_MSS1_E023 1 1 0 0 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 0 0 1 0 0 0 1
## K11092 K11093 K11108 K11126 K11129 K11131 K11136 K11137 K11143
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 1 1 0 1 0
## TOPAZ_MSS1_E023 1 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E026 0 1 1 0 1 1 1 1 0
## K11155 K11166 K11168 K11175 K11204 K11206 K11209 K11251 K11252
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 0 1 0 1 1 0
## TOPAZ_MSS1_E004 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 1 0 0 1 1 0 1 1
## TOPAZ_MSS1_E023 1 0 0 1 1 0 1 0 1
## TOPAZ_MSS1_E026 1 0 1 0 0 0 1 1 0
## K11253 K11254 K11262 K11267 K11268 K11269 K11271 K11274 K11292
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 1 0 1 1 0 0
## TOPAZ_MSS1_E023 0 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K11293 K11294 K11303 K11314 K11323 K11324 K11338 K11341 K11344
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 0 0 1
## TOPAZ_MSS1_E004 0 1 0 0 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 0 1 0 1 1 0 1
## TOPAZ_MSS1_E023 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 0 0 0 1
## K11352 K11353 K11364 K11414 K11416 K11426 K11434 K11462 K11463
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E004 0 0 1 1 0 1 0 0 1
## TOPAZ_MSS1_E011 0 0 1 0 0 1 0 0 1
## TOPAZ_MSS1_E023 0 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 0 1
## K11477 K11491 K11492 K11493 K11495 K11497 K11502 K11514 K11547
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 0 0 0 1 0 1 1
## TOPAZ_MSS1_E011 1 1 1 1 0 0 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 0 1 0 1 1 0 0
## K11548 K11549 K11550 K11583 K11594 K11599 K11600 K11644 K11654
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E011 1 1 0 1 1 0 1 1 1
## TOPAZ_MSS1_E023 1 1 1 1 0 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K11662 K11664 K11717 K11718 K11749 K11754 K11805 K11806 K11808
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E023 0 0 0 1 0 0 0 1 0
## TOPAZ_MSS1_E026 0 1 0 1 0 0 1 1 1
## K11824 K11826 K11827 K11836 K11838 K11843 K11854 K11857 K11863
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 0 0 1 1 0 1 0
## TOPAZ_MSS1_E011 1 1 0 0 1 0 1 0 1
## TOPAZ_MSS1_E023 1 0 0 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 0 0 1 1 1 1 1 0
## K11864 K11877 K11878 K11883 K11885 K11968 K11976 K11984 K11991
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 0 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 0 0 0 1 0 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 0 0
## TOPAZ_MSS1_E026 1 0 1 1 0 0 0 1 0
## K12160 K12175 K12177 K12178 K12180 K12183 K12184 K12185 K12188
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E011 1 0 0 1 0 0 1 0 0
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E026 1 0 0 1 1 0 1 1 1
## K12190 K12195 K12197 K12244 K12251 K12275 K12304 K12307 K12310
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 0 1 0 0
## TOPAZ_MSS1_E011 0 1 0 1 1 0 0 0 1
## TOPAZ_MSS1_E023 1 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 0 1 1 1 1
## K12343 K12345 K12349 K12373 K12389 K12391 K12392 K12394 K12396
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E011 1 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E023 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 0 1
## K12399 K12400 K12401 K12447 K12450 K12471 K12479 K12483 K12484
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 1 0 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 0 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 0
## K12486 K12524 K12571 K12580 K12581 K12584 K12585 K12592 K12602
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 0 0 1
## TOPAZ_MSS1_E004 0 1 1 1 0 0 1 1 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 0 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 0 0 1 1 0 1 1 0
## K12604 K12605 K12606 K12607 K12608 K12613 K12616 K12618 K12619
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 1 0 0 1 0
## TOPAZ_MSS1_E026 1 1 0 1 1 1 0 1 0
## K12622 K12623 K12624 K12626 K12627 K12655 K12657 K12662 K12733
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 0 1 0 1 0
## TOPAZ_MSS1_E011 0 1 0 0 0 0 1 0 0
## TOPAZ_MSS1_E023 0 0 1 1 1 1 0 0 0
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K12736 K12737 K12811 K12812 K12813 K12815 K12816 K12817 K12818
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 0 0 0 0 1 1 0 0
## TOPAZ_MSS1_E023 0 1 1 0 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 0
## K12819 K12822 K12823 K12825 K12827 K12828 K12829 K12830 K12837
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 0 1 1 1 0
## TOPAZ_MSS1_E004 1 0 0 1 0 1 1 0 1
## TOPAZ_MSS1_E011 0 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 0 0 0 0 1 1 1 0
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 0
## K12842 K12843 K12844 K12845 K12848 K12850 K12852 K12854 K12855
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 1 0 1 0 0 1 0 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 0 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K12856 K12858 K12859 K12860 K12861 K12862 K12863 K12864 K12867
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 0 0 0 1 1
## TOPAZ_MSS1_E011 0 1 0 0 1 0 1 0 1
## TOPAZ_MSS1_E023 0 1 0 1 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K12868 K12869 K12870 K12871 K12872 K12874 K12876 K12878 K12879
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E011 0 1 0 0 1 1 0 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 0 0 0 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 1 1
## K12883 K13024 K13025 K13026 K13049 K13051 K13091 K13094 K13095
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E004 0 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E011 0 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 1 0 1 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 0 0 0 1 1
## K13096 K13099 K13100 K13101 K13102 K13103 K13104 K13105 K13106
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E004 1 0 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 1 1 0 0 1 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 1 0 0 1 1
## TOPAZ_MSS1_E026 0 1 1 0 1 0 0 1 1
## K13108 K13109 K13110 K13111 K13113 K13118 K13123 K13125 K13126
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 1 0 1 0 1
## TOPAZ_MSS1_E011 1 0 0 1 1 0 1 0 1
## TOPAZ_MSS1_E023 0 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K13127 K13130 K13137 K13151 K13169 K13171 K13172 K13174 K13176
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 0 0 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 0 0 1 1 0 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E026 1 0 1 1 0 1 1 1 1
## K13179 K13205 K13206 K13207 K13220 K13280 K13337 K13338 K13342
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E011 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 0 1 0 1 1 1
## K13345 K13348 K13379 K13412 K13444 K13485 K13510 K13511 K13525
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 0 0 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 0 1 0 1 1 0 1 0 0
## TOPAZ_MSS1_E023 0 1 0 0 1 0 0 1 0
## TOPAZ_MSS1_E026 1 1 0 0 1 0 0 1 0
## K13566 K13606 K13667 K13690 K13706 K13711 K13717 K13719 K13728
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 0 0 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 0 1 1 0
## TOPAZ_MSS1_E023 1 0 1 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 0 1 0 0 0 1 1 1
## K13754 K13766 K13789 K13806 K13807 K13811 K13960 K13989 K14005
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 0 1 1 1 0 1
## TOPAZ_MSS1_E004 0 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 1 0 1 0 1 1 0 0
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 0 1 1
## K14006 K14007 K14015 K14016 K14018 K14050 K14058 K14066 K14157
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 1 1 0 1 0 1 0 1
## TOPAZ_MSS1_E023 1 1 1 0 0 0 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 0 1
## K14191 K14209 K14213 K14288 K14289 K14290 K14292 K14293 K14294
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E023 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K14297 K14301 K14304 K14306 K14309 K14312 K14319 K14320 K14324
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 0 0 1 1 0
## TOPAZ_MSS1_E004 1 1 0 1 0 0 1 0 1
## TOPAZ_MSS1_E011 0 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E023 1 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E026 1 1 0 1 0 0 1 1 0
## K14326 K14327 K14347 K14376 K14379 K14396 K14399 K14402 K14403
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 0 0 1 1 1 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 0 0 1 0
## K14404 K14408 K14440 K14445 K14455 K14521 K14536 K14538 K14539
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E023 1 0 1 1 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K14544 K14545 K14546 K14548 K14549 K14550 K14552 K14553 K14554
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 1 0 0 1 0 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K14555 K14556 K14558 K14559 K14560 K14563 K14564 K14565 K14566
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 1 0 0 1 0 1 0 0
## TOPAZ_MSS1_E023 0 1 0 1 1 0 0 0 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K14567 K14568 K14569 K14570 K14572 K14573 K14574 K14617 K14648
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E011 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E023 0 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K14652 K14677 K14684 K14685 K14686 K14696 K14709 K14717 K14721
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 0 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 0 1 1 0 0 0 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E026 1 0 0 0 1 1 1 0 1
## K14731 K14753 K14765 K14766 K14767 K14768 K14769 K14771 K14772
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 0 0 1
## TOPAZ_MSS1_E004 0 0 1 1 1 0 1 0 0
## TOPAZ_MSS1_E011 0 0 0 1 1 1 1 0 1
## TOPAZ_MSS1_E023 0 0 0 0 0 1 1 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 0 0 1
## K14774 K14777 K14779 K14782 K14784 K14785 K14786 K14787 K14788
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 1 1 1 1
## TOPAZ_MSS1_E023 1 0 0 0 0 1 1 1 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 1 1 0
## K14790 K14791 K14792 K14793 K14794 K14795 K14798 K14799 K14801
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 1 0 1 0 0
## TOPAZ_MSS1_E011 1 1 1 0 0 1 0 0 1
## TOPAZ_MSS1_E023 0 1 0 0 1 1 1 1 0
## TOPAZ_MSS1_E026 0 0 0 1 1 1 1 0 1
## K14805 K14806 K14808 K14810 K14811 K14815 K14818 K14821 K14823
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 0 0 1 0 0 0 0 1
## TOPAZ_MSS1_E023 0 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K14824 K14827 K14829 K14830 K14833 K14834 K14835 K14837 K14838
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 0 0 0 1 1 1 1 1
## TOPAZ_MSS1_E023 1 0 0 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 0 1 1 1 1
## K14842 K14843 K14844 K14846 K14849 K14850 K14851 K14852 K14855
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 0 1 1 1 0 1
## TOPAZ_MSS1_E011 0 0 1 1 0 0 0 1 1
## TOPAZ_MSS1_E023 1 1 1 0 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K14856 K14857 K14864 K14943 K14950 K14961 K14963 K14964 K14998
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 0 0 1 1 0 0 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K15013 K15014 K15025 K15026 K15029 K15032 K15033 K15042 K15044
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 1 1 0
## TOPAZ_MSS1_E011 0 1 1 1 0 1 1 1 0
## TOPAZ_MSS1_E023 1 0 0 1 0 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 0 0 1 1
## K15078 K15102 K15111 K15113 K15115 K15128 K15153 K15171 K15172
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 0 0 1 1
## TOPAZ_MSS1_E011 1 1 1 1 1 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E026 0 1 1 1 0 1 1 1 0
## K15174 K15176 K15177 K15178 K15196 K15198 K15202 K15216 K15223
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 0 0 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 0 0 1 0 0 0 1 0
## TOPAZ_MSS1_E023 1 1 0 0 0 1 0 0 1
## TOPAZ_MSS1_E026 1 1 0 1 1 0 0 1 1
## K15255 K15258 K15262 K15263 K15271 K15272 K15276 K15280 K15283
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 0 1 1 1 0
## TOPAZ_MSS1_E004 1 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 1 0 1 0 1 1 0 1
## TOPAZ_MSS1_E023 1 1 1 0 0 1 1 1 0
## TOPAZ_MSS1_E026 1 1 0 0 0 1 1 1 0
## K15285 K15287 K15289 K15296 K15303 K15326 K15331 K15333 K15336
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E023 1 1 1 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 0 1 0 1 1 1 1 1
## K15363 K15371 K15376 K15382 K15397 K15423 K15424 K15429 K15430
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 0 0 0 1 0 1
## TOPAZ_MSS1_E011 0 1 0 1 0 0 0 1 0
## TOPAZ_MSS1_E023 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 0 0 1 1 1 1
## K15436 K15441 K15442 K15443 K15448 K15449 K15463 K15498 K15523
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 0 1
## TOPAZ_MSS1_E004 1 0 0 0 1 0 1 0 1
## TOPAZ_MSS1_E011 1 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 0 1 1 0 1 0 0
## K15528 K15537 K15538 K15627 K15631 K15687 K15693 K15698 K15707
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 0 0 0
## TOPAZ_MSS1_E004 0 0 1 1 0 0 1 0 0
## TOPAZ_MSS1_E011 1 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E023 0 1 1 0 1 1 0 0 0
## TOPAZ_MSS1_E026 1 1 0 1 1 1 0 0 0
## K15710 K15716 K15731 K15744 K15777 K15789 K15865 K15918 K15923
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 1 1 0 0 1
## TOPAZ_MSS1_E004 1 0 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 1 1 0 0 1 1 0 1 1
## TOPAZ_MSS1_E023 1 0 0 0 1 1 1 0 1
## TOPAZ_MSS1_E026 1 0 1 0 1 1 0 0 1
## K15984 K16075 K16186 K16190 K16196 K16280 K16302 K16329 K16455
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 0 1 1 0 1
## TOPAZ_MSS1_E004 0 1 0 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 1 0 1 0 1 1 0 0
## TOPAZ_MSS1_E023 0 1 0 1 0 1 1 0 1
## TOPAZ_MSS1_E026 0 0 1 1 0 1 1 0 1
## K16458 K16461 K16462 K16470 K16473 K16474 K16478 K16482 K16487
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 0 0 1 0 1 0
## TOPAZ_MSS1_E011 0 1 1 0 1 0 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K16489 K16546 K16547 K16569 K16571 K16578 K16599 K16601 K16603
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 0 1 1 0 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 0 1 0 1 0
## TOPAZ_MSS1_E023 1 0 0 1 0 0 0 1 1
## TOPAZ_MSS1_E026 1 0 0 1 1 0 0 1 1
## K16606 K16608 K16732 K16743 K16744 K16745 K16746 K16747 K16748
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 0 0 0 0 1
## TOPAZ_MSS1_E011 0 1 1 0 0 1 0 1 1
## TOPAZ_MSS1_E023 0 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K16749 K16755 K16781 K16802 K16803 K16810 K16812 K16833 K16841
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 0 1 1 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 1 0 0 1 1 1 0 1
## TOPAZ_MSS1_E023 0 0 1 0 1 0 1 1 0
## TOPAZ_MSS1_E026 0 1 1 1 1 0 1 1 0
## K16842 K16865 K16904 K16911 K16912 K17065 K17085 K17086 K17087
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 0 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E023 1 0 1 1 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 0
## K17108 K17231 K17255 K17260 K17261 K17263 K17266 K17267 K17278
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 0 0 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 0 0 1 0 0 0 1
## TOPAZ_MSS1_E023 1 1 1 1 1 1 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 0 1
## K17292 K17302 K17339 K17361 K17362 K17408 K17411 K17412 K17424
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 0 1 0 1
## TOPAZ_MSS1_E004 1 1 0 0 0 1 1 0 1
## TOPAZ_MSS1_E011 0 1 0 1 1 0 1 1 0
## TOPAZ_MSS1_E023 1 0 1 1 1 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 0 0 1 0 1
## K17428 K17491 K17496 K17497 K17498 K17499 K17508 K17545 K17550
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 0 0 1 1 0 0 0 1
## TOPAZ_MSS1_E011 0 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E023 0 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 0 0 1 0 1 1 1 1
## K17553 K17560 K17570 K17579 K17580 K17583 K17584 K17592 K17600
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 0 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E023 1 0 1 0 1 0 1 0 1
## TOPAZ_MSS1_E026 0 0 1 0 1 0 1 1 1
## K17605 K17606 K17607 K17609 K17616 K17618 K17619 K17662 K17675
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E023 0 0 1 1 0 0 1 1 0
## TOPAZ_MSS1_E026 0 1 0 1 1 1 1 1 1
## K17681 K17743 K17757 K17776 K17783 K17785 K17794 K17796 K17800
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 0 1 0 1 0 1
## TOPAZ_MSS1_E011 0 0 0 0 1 1 0 0 1
## TOPAZ_MSS1_E023 1 0 0 0 1 0 0 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 0 1 1
## K17803 K17807 K17808 K17866 K17867 K17868 K17872 K17878 K17888
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 1 0 0 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 1 1 0 1 0 1 1 1 0
## TOPAZ_MSS1_E023 1 1 1 0 1 1 0 0 0
## TOPAZ_MSS1_E026 1 0 0 0 1 0 0 1 1
## K17893 K17907 K17911 K17917 K17943 K17972 K17973 K17981 K17987
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 1 0 1 1 0
## TOPAZ_MSS1_E004 0 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 1 0 1 0 1 1
## TOPAZ_MSS1_E023 0 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E026 0 1 0 1 1 0 1 1 0
## K17989 K18041 K18043 K18078 K18106 K18121 K18159 K18162 K18163
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E004 0 0 0 0 1 1 0 1 1
## TOPAZ_MSS1_E011 0 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E023 0 0 1 0 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 0 0 1 1 1 0
## K18164 K18170 K18182 K18189 K18192 K18201 K18208 K18272 K18328
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 1 1 1 1
## TOPAZ_MSS1_E011 1 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E023 0 1 1 1 0 1 1 1 0
## TOPAZ_MSS1_E026 0 1 1 1 0 1 1 1 1
## K18399 K18422 K18423 K18426 K18447 K18460 K18461 K18462 K18464
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E023 0 0 0 0 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K18465 K18466 K18467 K18468 K18469 K18477 K18532 K18550 K18584
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 0 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E023 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 0 0 1 0
## K18588 K18592 K18624 K18633 K18635 K18643 K18660 K18663 K18667
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 0 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 0 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 0 0 1 1 0 0 0
## TOPAZ_MSS1_E023 1 0 0 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 0 0 1 1 1 0 1 1
## K18710 K18726 K18749 K18752 K18763 K18802 K18849 K18850 K18932
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 1 0 0 1 0 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 0 0 1 1 0 1 1 0 0
## TOPAZ_MSS1_E023 0 0 0 1 0 0 1 0 1
## TOPAZ_MSS1_E026 1 0 1 1 0 0 1 0 1
## K18953 K18999 K19001 K19073 K19176 K19199 K19219 K19267 K19269
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 0 1 1 1 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 0 1 0 0 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 0 0 0 0
## TOPAZ_MSS1_E026 1 1 0 0 1 1 1 0 0
## K19307 K19323 K19332 K19348 K19352 K19362 K19365 K19375 K19400
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 0 0 1 1 1 1 0 0
## TOPAZ_MSS1_E023 1 0 1 1 0 1 0 0 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 1 1 1
## K19469 K19476 K19539 K19589 K19600 K19603 K19619 K19671 K19672
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E023 0 1 1 0 1 0 1 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 0 0 1 1
## K19674 K19676 K19677 K19679 K19680 K19681 K19683 K19684 K19685
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 1 1 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K19745 K19750 K19751 K19752 K19753 K19754 K19756 K19757 K19758
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E023 0 1 0 1 1 0 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 0 1 1 1
## K19759 K19760 K19761 K19765 K19787 K19801 K19882 K19936 K19941
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 0 0 1 1 1 1 0
## TOPAZ_MSS1_E004 0 1 0 0 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 1 1 1 0 1
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K19942 K19998 K20003 K20032 K20098 K20103 K20131 K20163 K20167
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E011 1 0 1 1 1 1 1 0 0
## TOPAZ_MSS1_E023 1 0 1 1 0 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K20178 K20179 K20180 K20181 K20182 K20184 K20221 K20222 K20223
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 0 0 0 1 1 1 0
## TOPAZ_MSS1_E023 0 1 1 0 0 0 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K20241 K20247 K20280 K20286 K20288 K20289 K20292 K20293 K20294
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 0 0 0 1 1 1 0 1
## TOPAZ_MSS1_E023 0 0 0 1 1 1 0 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 0 1 1
## K20295 K20296 K20298 K20299 K20301 K20303 K20305 K20307 K20309
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E023 0 1 1 1 1 1 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K20310 K20359 K20360 K20362 K20363 K20369 K20371 K20404 K20406
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 0 1 0 1 0 0
## TOPAZ_MSS1_E004 1 0 0 1 0 0 1 1 0
## TOPAZ_MSS1_E011 1 0 1 0 1 1 0 1 1
## TOPAZ_MSS1_E023 1 0 0 1 1 0 1 0 0
## TOPAZ_MSS1_E026 1 0 1 1 1 0 1 1 0
## K20407 K20471 K20523 K20607 K20649 K20726 K20776 K20781 K20791
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 1 0 0 1 0 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 0 0 1 1 0 1 1 1 0
## TOPAZ_MSS1_E023 0 0 1 0 0 1 0 0 1
## TOPAZ_MSS1_E026 0 1 1 0 0 1 0 0 1
## K20792 K20793 K20794 K20823 K20827 K20899 K21029 K21052 K21195
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 1 0 0 1 0 1 0 1 0
## TOPAZ_MSS1_E023 0 1 1 1 0 0 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K21249 K21396 K21456 K21480 K21552 K21749 K21767 K21773 K21776
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 0 1 0 1 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E011 0 1 0 1 0 0 1 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 0 1 0 0
## TOPAZ_MSS1_E026 1 1 1 0 1 0 1 0 1
## K21777 K21813 K21814 K21841 K21843 K21850 K21866 K21989 K21991
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 0 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E023 0 0 1 1 1 0 1 1 0
## TOPAZ_MSS1_E026 1 0 1 1 1 0 1 1 1
## K22063 K22068 K22069 K22074 K22132 K22182 K22210 K22278 K22366
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 0 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 1 0 0 0 1 1 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 0 1
## K22377 K22382 K22384 K22390 K22399 K22443 K22503 K22522 K22530
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 0 0 1 0 0 1 1 0
## TOPAZ_MSS1_E004 1 1 0 1 1 0 1 0 1
## TOPAZ_MSS1_E011 0 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 1 1 0 1 0 0
## TOPAZ_MSS1_E026 0 0 0 1 1 0 1 1 0
## K22531 K22533 K22544 K22556 K22557 K22558 K22561 K22563 K22565
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 0 0 1 0
## TOPAZ_MSS1_E011 1 0 1 0 0 1 0 1 0
## TOPAZ_MSS1_E023 1 0 1 0 0 1 0 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 0 0 1
## K22566 K22579 K22611 K22641 K22647 K22685 K22721 K22733 K22746
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E011 0 0 0 1 1 1 1 1 0
## TOPAZ_MSS1_E023 1 0 0 1 1 0 1 1 0
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K22748 K22754 K22761 K22762 K22763 K22766 K22803 K22804 K22817
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 0 1 0 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E011 0 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 0 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 0 1 1
## K22825 K22855 K22856 K22857 K22858 K22868 K22869 K22900 K22913
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 0 1 0 1 0 1 1
## TOPAZ_MSS1_E004 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E011 0 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E023 0 1 0 1 0 0 0 1 0
## TOPAZ_MSS1_E026 1 1 0 1 0 0 0 1 1
## K22935 K22936 K22940 K22943 K22985 K22987 K23010 K23025 K23029
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 0 1 0 1
## TOPAZ_MSS1_E004 0 0 1 0 1 1 1 0 1
## TOPAZ_MSS1_E011 1 0 1 0 1 0 0 1 1
## TOPAZ_MSS1_E023 0 1 0 0 1 0 1 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 0 1 1 1
## K23040 K23093 K23114 K23222 K23288 K23289 K23308 K23309 K23313
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 0 1 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 1 0 1 1 1 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 1 1 1 0
## TOPAZ_MSS1_E023 0 1 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 1 1 1 0 1 0 0 1
## K23314 K23341 K23343 K23398 K23404 K23424 K23437 K23438 K23439
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 0 1 0 1 0 1 1
## TOPAZ_MSS1_E023 1 0 1 1 1 1 0 1 0
## TOPAZ_MSS1_E026 1 0 1 1 0 1 1 1 1
## K23460 K23485 K23518 K23538 K23539 K23555 K23562 K23565 K23566
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E004 1 1 0 1 0 1 1 0 1
## TOPAZ_MSS1_E011 0 0 1 0 1 1 1 0 1
## TOPAZ_MSS1_E023 0 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K23567 K23568 K23643 K23677 K23788 K23802 K23877 K23878 K23948
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 0 0 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E011 1 0 1 1 0 0 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 0 1
## K23952 K23966 K23978 K23994 K24029 K24104 K24139 K24175 K24194
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 0
## TOPAZ_MSS1_E004 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 0 0 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 0
## K24205 K24223 K24226 K24228 K24230 K24272 K24348 K24350 NoKID
## TOPAZ_IOS1_E045 1 1 1 1 1 1 1 1 1
## TOPAZ_MSD1_E003 1 0 1 1 1 1 0 1 1
## TOPAZ_MSS1_E004 0 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E011 1 0 1 0 0 1 1 0 1
## TOPAZ_MSS1_E023 1 0 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 0 0 1 1 1 1 0 0 1
## K00006 K00019 K00020 K00079 K00101 K00106 K00109 K00138 K00162
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E011 0 0 1 0 0 0 1 0 0
## TOPAZ_MSS1_E023 1 0 1 0 1 0 0 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K00163 K00207 K00213 K00227 K00236 K00265 K00273 K00274 K00275
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K00276 K00290 K00314 K00355 K00357 K00381 K00390 K00416 K00417
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 1 0 0 0 1 1 0 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 1 1
## K00456 K00469 K00476 K00505 K00569 K00574 K00611 K00613 K00616
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 1 1 0 0
## TOPAZ_MSS1_E023 0 0 1 0 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K00621 K00624 K00632 K00637 K00643 K00649 K00677 K00698 K00710
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 0 1 1
## K00748 K00757 K00759 K00760 K00761 K00763 K00772 K00794 K00800
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 1 1 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 1 0 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K00801 K00803 K00845 K00846 K00851 K00853 K00888 K00898 K00899
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 1 1
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 1 0 1 0 0 0 1 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K00912 K00938 K00949 K00953 K00967 K00968 K00969 K00979 K00999
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 0 1 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K01011 K01013 K01045 K01047 K01051 K01052 K01056 K01065 K01077
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 0 0
## K01106 K01107 K01110 K01114 K01125 K01126 K01134 K01166 K01173
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 1 1 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 1 1 0 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K01178 K01185 K01190 K01191 K01197 K01202 K01209 K01217 K01218
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 0 1 0 1 0 0
## TOPAZ_MSS1_E011 0 0 1 0 1 0 1 0 0
## TOPAZ_MSS1_E023 0 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K01224 K01246 K01275 K01278 K01285 K01369 K01372 K01404 K01419
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 1 0 0 0 0 1
## TOPAZ_MSS1_E023 0 0 1 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K01425 K01431 K01432 K01444 K01464 K01466 K01469 K01514 K01522
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 0 1 1 0 1 1 0
## TOPAZ_MSS1_E026 1 1 0 0 1 1 1 1 1
## K01580 K01581 K01593 K01597 K01613 K01619 K01627 K01637 K01649
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 1 1 0 0 0 1
## TOPAZ_MSS1_E023 1 0 1 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K01669 K01673 K01693 K01698 K01705 K01711 K01739 K01752 K01758
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 1 0 1 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K01768 K01779 K01787 K01796 K01805 K01808 K01814 K01824 K01836
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 0 0 0 0 0 1
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 1 0 1 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K01907 K01940 K01942 K01966 K02139 K02152 K02153 K02169 K02199
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E023 0 1 0 1 1 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K02265 K02266 K02303 K02318 K02335 K02342 K02349 K02357 K02362
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 1 0 0 1 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 1 0 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K02437 K02510 K02575 K02605 K02607 K02725 K02727 K02729 K02730
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 1 1 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 0 0 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 0 1
## K02731 K02734 K02739 K02866 K02867 K02879 K02880 K02882 K02883
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 0 0 0 1 0
## TOPAZ_MSS1_E011 1 1 0 1 1 0 1 1 0
## TOPAZ_MSS1_E023 1 1 1 0 1 0 0 1 0
## TOPAZ_MSS1_E026 0 1 1 0 1 1 1 1 1
## K02890 K02897 K02899 K02900 K02906 K02908 K02910 K02911 K02913
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 0 1 1 0 0 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K02916 K02919 K02924 K02932 K02938 K02940 K02947 K02955 K02957
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 0 1 0 0 0
## TOPAZ_MSS1_E011 0 0 1 0 1 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K02958 K02961 K02964 K02966 K02970 K02971 K02973 K02974 K02976
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 0 0 1 1
## TOPAZ_MSS1_E011 0 0 0 0 1 0 0 0 1
## TOPAZ_MSS1_E023 0 1 0 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K02977 K02980 K02990 K02993 K03005 K03007 K03008 K03009 K03012
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 1 0 1 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K03015 K03017 K03021 K03064 K03065 K03066 K03104 K03109 K03113
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 0 1 0 0 1
## TOPAZ_MSS1_E011 0 1 0 0 0 0 0 0 1
## TOPAZ_MSS1_E023 1 1 0 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 0 1 0 1 0 1 1 1
## K03120 K03123 K03124 K03126 K03133 K03136 K03139 K03144 K03151
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 1 0 0 1 0
## TOPAZ_MSS1_E011 0 1 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 0 0 1 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K03188 K03234 K03238 K03240 K03241 K03255 K03282 K03348 K03364
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 0 0 1 0 0
## TOPAZ_MSS1_E011 0 1 1 0 1 0 0 1 0
## TOPAZ_MSS1_E023 1 0 0 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 0
## K03392 K03430 K03514 K03522 K03537 K03539 K03553 K03610 K03639
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 0 0 0 0 1
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 0 1 1 0 0 1 0 1
## TOPAZ_MSS1_E026 0 1 1 1 0 1 0 1 1
## K03679 K03681 K03691 K03801 K03845 K03859 K03860 K03872 K03926
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 0 0 0 1 0
## TOPAZ_MSS1_E011 0 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K03937 K03938 K03939 K03953 K03954 K03955 K04063 K04095 K04382
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 0 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 0 1 0 1 1 1 1
## K04496 K04505 K04506 K04708 K04711 K04713 K04728 K04802 K05016
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 0 0 0 1 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 1 0 0 1 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 0 0 1
## K05275 K05285 K05288 K05289 K05291 K05302 K05310 K05357 K05528
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 0 0 0 1 0
## TOPAZ_MSS1_E026 0 1 1 1 1 1 0 1 1
## K05544 K05607 K05609 K05678 K05754 K05759 K05767 K05850 K05917
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 0 0 1 0 0 1
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 0 0 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K06058 K06125 K06170 K06627 K06630 K06634 K06664 K06670 K06685
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 1 0 0 0 0 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 0 1 1
## K06700 K06711 K06902 K06910 K06927 K06963 K07001 K07006 K07025
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E011 0 0 1 0 1 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K07089 K07098 K07106 K07107 K07117 K07118 K07124 K07199 K07207
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E023 0 0 1 1 0 1 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K07342 K07393 K07404 K07447 K07515 K07517 K07753 K07891 K07910
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 1 0
## TOPAZ_MSS1_E011 0 1 0 1 1 1 0 1 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 0 1
## K07931 K07933 K07936 K07952 K08057 K08074 K08098 K08175 K08176
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K08339 K08494 K08504 K08507 K08511 K08517 K08592 K08597 K08654
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 0 0 0 1 0
## TOPAZ_MSS1_E011 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 0 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K08657 K08675 K08683 K08726 K08738 K08740 K08764 K08775 K08776
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 0 1 1 0 1 0
## TOPAZ_MSS1_E011 0 1 0 0 1 0 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 1 0 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 0
## K08864 K08873 K08989 K09001 K09252 K09273 K09288 K09478 K09493
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E023 0 1 1 1 0 1 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K09497 K09516 K09539 K09548 K09550 K09561 K09562 K09567 K09569
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 1 0 1 1 0 1 0 0
## TOPAZ_MSS1_E023 0 0 1 1 1 1 1 0 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 0 1
## K09571 K09584 K09586 K09592 K09645 K09648 K09650 K09765 K09955
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 1 0 0 1 0 0
## TOPAZ_MSS1_E023 0 0 0 0 1 0 1 0 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K09966 K10046 K10104 K10144 K10270 K10301 K10365 K10391 K10426
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 0 0 0 1 0
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E023 0 1 0 1 0 0 1 0 0
## TOPAZ_MSS1_E026 1 1 0 1 0 1 1 0 1
## K10570 K10572 K10578 K10579 K10583 K10585 K10606 K10632 K10644
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 0 1 0 0
## TOPAZ_MSS1_E011 0 0 1 1 1 0 0 0 0
## TOPAZ_MSS1_E023 1 0 1 0 1 1 0 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K10666 K10695 K10706 K10735 K10742 K10743 K10744 K10750 K10752
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 0 1 0 1 1
## TOPAZ_MSS1_E011 0 0 0 1 1 0 0 1 0
## TOPAZ_MSS1_E023 0 1 0 1 1 0 1 0 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K10755 K10776 K10801 K10804 K10841 K10842 K10847 K10849 K10871
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 1 0 0 0 0
## TOPAZ_MSS1_E011 1 0 0 0 1 0 1 0 0
## TOPAZ_MSS1_E023 0 0 0 0 1 0 1 1 0
## TOPAZ_MSS1_E026 1 0 0 1 1 1 0 1 1
## K10880 K11088 K11090 K11096 K11097 K11098 K11099 K11109 K11135
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 1 1 0 0 1
## TOPAZ_MSS1_E011 0 0 0 1 1 0 0 0 1
## TOPAZ_MSS1_E023 0 1 1 0 1 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K11163 K11173 K11187 K11259 K11270 K11273 K11275 K11308 K11322
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 1 0 0 1
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E023 1 1 0 0 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K11339 K11363 K11368 K11412 K11431 K11438 K11490 K11498 K11529
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 1 1 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E026 0 1 0 0 1 1 1 0 1
## K11564 K11577 K11578 K11584 K11673 K11674 K11681 K11701 K11713
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E011 0 0 0 1 0 0 0 0 1
## TOPAZ_MSS1_E023 1 1 0 1 0 0 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 1 1
## K11714 K11731 K11744 K11752 K11790 K11793 K11851 K11855 K11858
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 0 1 1 1 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K11884 K11971 K11975 K11979 K11995 K12162 K12164 K12165 K12176
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K12179 K12181 K12189 K12194 K12196 K12198 K12261 K12262 K12306
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 0 1 0 0 0
## TOPAZ_MSS1_E011 0 0 0 1 1 1 0 1 1
## TOPAZ_MSS1_E023 0 1 1 0 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 0 1
## K12308 K12381 K12386 K12393 K12398 K12402 K12403 K12481 K12489
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 1 1 1 1 0 0
## TOPAZ_MSS1_E011 0 0 1 0 1 0 0 1 0
## TOPAZ_MSS1_E023 0 1 1 1 1 0 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 0 1
## K12493 K12572 K12587 K12589 K12590 K12593 K12597 K12614 K12621
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 0 0 0 1 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E023 1 0 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K12625 K12659 K12661 K12663 K12734 K12735 K12739 K12778 K12795
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 1 1 0 1 0
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 0 1
## TOPAZ_MSS1_E023 0 0 1 0 0 1 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 0 1 0 1 1
## K12820 K12826 K12832 K12834 K12836 K12839 K12840 K12846 K12847
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 0 0 0 0 0 1
## TOPAZ_MSS1_E011 1 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 0 0 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K12849 K12857 K12873 K12877 K12880 K12882 K12946 K12947 K13093
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E011 1 1 1 1 1 0 0 1 1
## TOPAZ_MSS1_E023 1 1 1 1 1 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K13115 K13116 K13119 K13120 K13121 K13124 K13149 K13175 K13181
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 1 0 0 0 0
## TOPAZ_MSS1_E011 0 1 0 1 0 0 0 0 1
## TOPAZ_MSS1_E023 1 1 1 0 1 0 0 0 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K13210 K13237 K13249 K13278 K13289 K13299 K13336 K13339 K13346
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E023 0 0 1 1 0 0 1 0 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K13347 K13354 K13355 K13356 K13431 K13507 K13528 K13539 K13617
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 1 1 0 0 0
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 0 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K13675 K13696 K13701 K13758 K13985 K13998 K14003 K14004 K14009
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 1 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E023 1 0 0 1 1 0 0 1 0
## TOPAZ_MSS1_E026 1 0 1 0 1 1 1 1 1
## K14026 K14274 K14299 K14307 K14310 K14315 K14328 K14358 K14360
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 1 0 0 0 1 1 0
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K14400 K14401 K14405 K14407 K14415 K14416 K14429 K14430 K14439
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 0 0 1 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K14525 K14557 K14561 K14589 K14621 K14638 K14640 K14649 K14676
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 0 0 0 1 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E023 1 0 1 0 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K14682 K14692 K14713 K14724 K14775 K14776 K14780 K14800 K14807
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 1 1
## TOPAZ_MSS1_E011 1 0 0 0 0 1 1 0 0
## TOPAZ_MSS1_E023 0 1 0 1 1 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K14816 K14820 K14831 K14832 K14839 K14841 K14847 K14848 K14859
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 1 1 0 1 1 0 1
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 0 1 0 1 0 0 1 1
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 1 1
## K14861 K14862 K14863 K14938 K14962 K14965 K14994 K14997 K15015
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 1 1 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 0 1 1 1
## K15027 K15028 K15030 K15040 K15075 K15083 K15085 K15100 K15104
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E026 0 1 1 1 1 1 1 1 1
## K15109 K15112 K15114 K15117 K15118 K15119 K15121 K15122 K15148
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K15190 K15210 K15235 K15264 K15275 K15277 K15278 K15284 K15286
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 0 1 0 0 0
## TOPAZ_MSS1_E011 1 0 0 1 0 1 0 0 0
## TOPAZ_MSS1_E023 0 0 0 1 1 1 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K15305 K15356 K15362 K15372 K15381 K15407 K15414 K15434 K15446
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 1 0 0 1 0 0 0 1
## TOPAZ_MSS1_E023 1 1 0 1 1 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 0 1
## K15450 K15532 K15542 K15544 K15559 K15633 K15691 K15866 K15889
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 1 0 0 1 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 1 0 1 0 0
## TOPAZ_MSS1_E026 1 1 0 1 1 1 0 1 1
## K15902 K15979 K16165 K16284 K16296 K16298 K16368 K16457 K16459
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 1 1 0 0 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K16465 K16538 K16540 K16575 K16576 K16639 K16742 K16754 K16765
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 0 0 0 0 1 0
## TOPAZ_MSS1_E011 1 1 0 0 0 1 1 0 0
## TOPAZ_MSS1_E023 1 1 1 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K16780 K16809 K17046 K17081 K17268 K17290 K17301 K17360 K17413
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E011 0 0 0 1 1 0 1 0 0
## TOPAZ_MSS1_E023 1 0 0 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 0 0 0 0 1 1
## K17422 K17427 K17430 K17434 K17435 K17500 K17541 K17601 K17623
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 1 1 0 1 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 1 0 1 0 1 1 0
## TOPAZ_MSS1_E026 0 0 1 1 1 1 1 1 1
## K17637 K17679 K17680 K17686 K17713 K17732 K17744 K17759 K17768
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E011 0 1 0 1 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 1 1 0 0 1 1 0
## TOPAZ_MSS1_E026 1 0 1 1 1 1 1 1 1
## K17769 K17777 K17778 K17780 K17784 K17790 K17795 K17804 K17805
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 1 1 0 1 1
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 1 1 0 0 1 1 1 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 0 1 1
## K17906 K17908 K17968 K18045 K18055 K18065 K18156 K18167 K18172
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 0 0 0 1 1
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 1 0
## TOPAZ_MSS1_E023 0 1 1 0 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K18195 K18334 K18342 K18404 K18441 K18442 K18443 K18463 K18586
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 1 0 1 0 1
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 0 1
## TOPAZ_MSS1_E023 1 1 1 0 1 0 0 1 1
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 0 1
## K18587 K18622 K18665 K18678 K18732 K18735 K18740 K18758 K18826
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 1 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 1 0 0 0 0 1
## TOPAZ_MSS1_E023 1 1 0 0 0 1 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K18914 K19054 K19055 K19200 K19306 K19355 K19370 K19371 K19372
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 1
## TOPAZ_MSS1_E011 0 0 0 1 1 0 0 0 1
## TOPAZ_MSS1_E023 0 1 1 1 0 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K19384 K19398 K19513 K19572 K19656 K19668 K19675 K19678 K19682
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 0 0 0 1 0
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 1 0
## TOPAZ_MSS1_E023 1 0 0 1 1 0 1 1 0
## TOPAZ_MSS1_E026 1 1 1 0 1 1 1 1 1
## K19788 K19870 K19937 K19983 K19984 K19985 K19986 K19995 K20028
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E011 1 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E023 1 0 1 0 0 0 0 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 0 1
## K20029 K20069 K20072 K20164 K20195 K20217 K20224 K20235 K20278
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 1 0 0 0 1 0 0 0
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 0 0 1 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K20290 K20300 K20304 K20306 K20308 K20318 K20367 K20368 K20372
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 0 0 1 1 0 0 1
## TOPAZ_MSS1_E011 1 0 0 0 1 0 1 0 0
## TOPAZ_MSS1_E023 1 1 1 0 1 1 1 0 1
## TOPAZ_MSS1_E026 1 0 0 0 1 0 1 1 1
## K20398 K20403 K20405 K20408 K20472 K20493 K20724 K20800 K20803
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 1 0 1 0 0 0 0
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 1 1 1 1 1 0 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K20824 K20844 K21196 K21248 K21398 K21437 K21626 K21842 K21844
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 1 0 1 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 1 1 0 1 0 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 0
## K21848 K21889 K22025 K22066 K22071 K22072 K22075 K22078 K22128
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E011 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 0 1 0 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 1 1 1
## K22193 K22282 K22379 K22438 K22555 K22559 K22560 K22562 K22564
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 1 1 0
## TOPAZ_MSS1_E011 0 0 0 1 0 0 1 0 0
## TOPAZ_MSS1_E023 0 0 0 1 0 0 1 1 1
## TOPAZ_MSS1_E026 1 0 1 0 1 1 1 1 1
## K22686 K22696 K22736 K22744 K22755 K22757 K22764 K22809 K22864
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 1 1 1 0 1 0 0 0
## TOPAZ_MSS1_E011 1 1 1 1 0 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 0 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 0 1
## K22866 K22867 K22888 K22928 K22939 K22966 K23002 K23113 K23166
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 1 1
## TOPAZ_MSS1_E011 0 0 0 0 1 0 0 0 0
## TOPAZ_MSS1_E023 1 1 0 1 0 1 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K23293 K23298 K23311 K23312 K23325 K23330 K23344 K23355 K23362
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 1 0 0 0
## TOPAZ_MSS1_E023 0 0 0 1 0 0 0 1 1
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K23387 K23490 K23503 K23541 K23564 K23569 K23678 K23741 K23845
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 1 0 0 0 1 1 0 0 1
## TOPAZ_MSS1_E011 1 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 0 0 0 1 1 1 0
## TOPAZ_MSS1_E026 1 0 1 1 0 1 1 1 1
## K23879 K23965 K24083 K24125 K24195 K24204 K24224 K24242 K24253
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E004 0 0 0 0 0 0 1 0 1
## TOPAZ_MSS1_E011 0 1 0 0 0 0 1 0 0
## TOPAZ_MSS1_E023 0 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E026 1 1 0 1 1 1 1 1 1
## K24353 K00099 K00295 K00545 K00697 K00728 K00878 K00971 K00986
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 1 0 0 0 0 0 0 0 0
## K01048 K01082 K01948 K02372 K02426 K02434 K02492 K02603 K02837
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 0 0 1 0 1 1 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K02881 K02891 K02898 K02968 K03024 K03098 K03116 K03152 K03245
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 0 0 0 1 1 1 0
## TOPAZ_MSS1_E023 0 0 0 0 1 0 0 0 0
## TOPAZ_MSS1_E026 0 0 1 0 0 0 0 0 0
## K03434 K03680 K03777 K03794 K03798 K03834 K04040 K04485 K05776
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 1 1 1 0 0 1 0 0 0
## TOPAZ_MSS1_E023 1 1 1 0 0 0 0 0 0
## TOPAZ_MSS1_E026 1 1 0 0 0 0 0 0 0
## K06147 K06632 K06920 K06950 K06969 K07054 K07934 K08336 K08596
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 1 0 0 0 0 0
## K08739 K08902 K08964 K08967 K09123 K09487 K09935 K10390 K10412
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K10436 K10609 K10766 K10777 K10867 K11145 K11446 K11511 K11643
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 0 0 0 0 0 1 0 0
## TOPAZ_MSS1_E026 1 0 0 1 0 0 1 0 0
## K11811 K11837 K12158 K12199 K12272 K12397 K12452 K12456 K12598
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 0 0 1 1 1 0 1
## TOPAZ_MSS1_E023 0 0 1 1 1 1 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 1 0 0 0 0
## K12620 K12821 K13107 K13238 K13273 K13800 K14137 K14537 K14840
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 1 1 1 0 0 1 0
## TOPAZ_MSS1_E023 1 0 1 0 0 0 0 0 1
## TOPAZ_MSS1_E026 1 0 1 0 0 0 0 1 0
## K15180 K15342 K15455 K16055 K16531 K16570 K16584 K16605 K16740
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 0 1 1 0 1 0 1 1
## TOPAZ_MSS1_E023 0 0 1 0 1 1 1 1 0
## TOPAZ_MSS1_E026 0 0 1 0 1 0 0 1 0
## K16771 K16801 K17103 K17262 K17285 K17969 K18187 K18204 K18668
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 1 1 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 1 0 0 0 0 0
## K18757 K18764 K19382 K19573 K19730 K20417 K20474 K20826 K20872
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E011 0 1 0 0 0 1 1 1 1
## TOPAZ_MSS1_E023 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K21768 K21971 K22745 K23499 K23570 K24229 K00254 K00285 K00549
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 1 1 1 1 1 1 0 0 0
## TOPAZ_MSS1_E011 0 1 1 0 1 0 1 1 1
## TOPAZ_MSS1_E023 1 1 0 0 1 1 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 1 0 0 0
## K00665 K00783 K00830 K00854 K00868 K00919 K01410 K01751 K02116
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 0 0 0 1 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 1 0 0 0 0
## K02431 K02830 K02928 K02998 K03800 K03969 K05681 K06995 K07192
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 0 1 0 1 0 0 0 0 1
## TOPAZ_MSS1_E026 0 1 1 1 0 0 0 0 1
## K07259 K08064 K08292 K08311 K08341 K08343 K08851 K09598 K10085
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 1 0 0 1 1 0 0
## K10290 K10295 K10427 K10534 K10838 K11128 K11130 K11518 K11982
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 0 0 1 0 0 1 1 1 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K12831 K12881 K13350 K13448 K14763 K14764 K14773 K14944 K16365
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 1 1 0 1 0 1 1 0 0
## TOPAZ_MSS1_E026 0 1 0 0 0 0 0 0 0
## K16815 K16903 K17402 K17598 K17782 K17871 K19755 K19784 K20027
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E023 0 0 1 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 1 0 0 0 0 0 0
## K21766 K22422 K22756 K22909 K23334 K23543 K23563 K00008 K00102
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 1 1 1 1 1 1 1 0 0
## TOPAZ_MSS1_E023 0 1 1 0 0 0 0 1 1
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 1
## K00122 K00130 K00253 K00331 K00550 K00667 K01244 K01494 K01638
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 0 0 0 0 0 0 1 1
## K01644 K01652 K01684 K01811 K01854 K01921 K02014 K02112 K02326
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 0 0 0 1 0 0 0 1
## K02527 K02892 K02922 K02949 K03000 K03358 K03646 K03940 K03963
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 0 0 0 0 1 0 0 0 1
## K03965 K04755 K05141 K05350 K05929 K06172 K06210 K06258 K06875
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 0 1 1 0 0 1
## K06928 K06965 K07042 K07056 K07071 K07877 K08371 K08762 K09191
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 0 0 1 1 1 0 0 0
## K09529 K09531 K09658 K09833 K10133 K10520 K10582 K10599 K10684
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 0 0 0 1 0 1 0 0
## K11001 K11366 K11699 K12193 K12591 K12603 K12948 K13177 K13443
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 0 0 0 1 1 1 0
## K13513 K14298 K14300 K14571 K14789 K14797 K14822 K15110 K15139
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 0 1 0 0 0 1 0 1 1
## K15146 K15175 K15192 K15323 K15360 K15425 K15507 K15680 K15728
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 0 1 1 0 0 0 0 1 1
## K15901 K15920 K16185 K16344 K16449 K16535 K16757 K17582 K17770
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 1 1 1 1 0 1 0 0 0
## K18046 K18166 K18177 K18180 K18185 K18482 K18577 K19399 K19612
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 0 1 0 0 0 1 0 0 0
## K19952 K20285 K20302 K20526 K20862 K22138 K22145 K22207 K22342
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 1 1 1 1
## TOPAZ_MSS1_E026 0 0 0 1 0 0 0 0 1
## K22843 K23552 K23886 K23953 K24134 K01495 K01512 K01721 K01974
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 1 1 1 1 1 0 0 0 0
## TOPAZ_MSS1_E026 1 1 0 0 0 1 1 1 1
## K02871 K03858 K06633 K08467 K10416 K10737 K10845 K10872 K11188
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K11853 K12200 K13128 K13250 K13341 K13343 K14809 K15181 K15377
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K15445 K15734 K17080 K18171 K18723 K19202 K21198 K22651 K22758
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 1 1 1 1 1 1 1 1 1
## K00058 K00333 K00457 K00464 K00471 K00542 K00592 K00597 K00627
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K00688 K00718 K00788 K00796 K00847 K00877 K00915 K00941 K00945
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K00950 K01006 K01055 K01097 K01118 K01174 K01179 K01515 K01565
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K01850 K02133 K02359 K02395 K02396 K02427 K02493 K02495 K02518
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K02533 K02537 K02904 K03187 K03281 K03286 K03331 K03365 K03540
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K03579 K03621 K03631 K03754 K04615 K05304 K06126 K06178 K06816
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K06975 K07140 K07213 K07300 K07752 K07765 K08497 K08852 K08901
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K09425 K10403 K10586 K10904 K11517 K11538 K11687 K11726 K11796
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K11886 K11964 K12173 K12410 K12462 K12599 K12833 K12865 K12875
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K13370 K13704 K13950 K14325 K14395 K14441 K14523 K14618 K14819
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K15053 K15201 K15227 K15281 K15332 K15977 K16219 K16342 K16600
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K16609 K16868 K17578 K17602 K17710 K17756 K17966 K17985 K18327
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K18669 K18670 K18730 K19033 K19720 K19737 K20096 K20101 K20291
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K20353 K20476 K20989 K21232 K21797 K22101 K22381 K22419 K22911
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K22942 K23327 K23333 K23498 K23628 K00067 K00325 K00335 K00599
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K00604 K00675 K00720 K00965 K01053 K01104 K01277 K01658 K01782
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K01817 K03678 K03737 K03791 K03944 K04596 K04597 K04598 K04722
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K05148 K05152 K05360 K05921 K06709 K07223 K08077 K08139 K08716
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K08766 K08794 K08818 K09250 K09659 K10258 K10580 K10604 K10761
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K10765 K11095 K11246 K11592 K11795 K11807 K11834 K11985 K12351
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K13335 K13524 K13830 K13907 K14001 K14262 K14291 K14313 K14411
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K14530 K14674 K14995 K15108 K15152 K15365 K15426 K15433 K15440
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K15637 K16602 K16857 K17543 K18158 K18178 K18188 K18270 K18666
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K18697 K19327 K19369 K19770 K20102 K20782 K20784 K21682 K21919
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K22139 K23012 K23295 K03231 K11848 K13344 K16794 K16914 K18183
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K19385 K22991 K00736 K02552 K02886 K03137 K06113 K14443 K14778
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K15516 K15732 K16330 K18213 K19373 K20798 K01012 K01607 K02639
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K03596 K08269 K10385 K16589 K17771 K01195 K02216 K03138 K03306
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K03696 K06204 K07478 K11437 K14845 K16761 K17094 K23553 K24135
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K24225 K01286 K01485 K02065 K03076 K03975 K08330 K10808 K13133
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K13621 K14164 K15340 K17725 K18787 K19996 K22904 K00074 K01100
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K01531 K02179 K02942 K03305 K03500 K03510 K04771 K05994 K10428
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K12418 K16297 K18649 K19035 K20477 K22387 K00833 K01935 K21891
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K23151 K09377 K16484 K01778 K01997 K03089 K03271 K03437 K03628
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K03770 K03832 K04654 K04656 K07010 K07303 K08307 K09696 K09697
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K12669 K14165 K20884 K20888 K11380 K00657 K03530 K03959 K06276
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K07095 K23339 K23542 K04563 K03741 K09577 K13707 K18798 K20092
## TOPAZ_IOS1_E045 0 0 0 0 0 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0 0 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0 0 0 0 0 0
## K21403 K01725 K18086 K11593
## TOPAZ_IOS1_E045 0 0 0 0
## TOPAZ_MSD1_E003 0 0 0 0
## TOPAZ_MSS1_E004 0 0 0 0
## TOPAZ_MSS1_E011 0 0 0 0
## TOPAZ_MSS1_E023 0 0 0 0
## TOPAZ_MSS1_E026 0 0 0 0# table(MAG_dendro_binary$BIN)
# ?pivot_widerlibrary(ggdendro)
cluster_mags <- hclust(dist((MAG_dendro_binary)), method = "average")
dendro_mags <- dendro_data(as.dendrogram(cluster_mags), type = "rectangle")
# head(dendro_mags)
labeled_dendro_order <- as.character(dendro_mags$labels$label)
# labeled_dendro_orderAdd trophy information
labs <- label(dendro_mags)
labs_refined <- labs %>%
mutate(group = case_when(
label %in% photo_mags ~ "Phototroph",
TRUE ~ "Heterotroph"
))
# head(labs_refined)Plot dendrogram - derived from the presence/absence of known orthologs
dendro_mag_plot <- ggplot(segment(dendro_mags)) +
geom_segment(aes(x = x, y = y, xend = xend,
yend = yend)) +
coord_flip() +
scale_y_reverse(expand = c(1, 1)) +
geom_text(aes(x = x, y = y, label = label, angle = 0,
hjust = 0, color = labs_refined$group),
data = label(dendro_mags), fontface = "bold", size = 5) +
scale_color_manual(values = c("#CC3D6D", "#B4CC3D")) +
theme_dendro() +
theme(legend.position = "bottom", legend.title = element_blank())# svg("dendrogram-plot-trophy.svg", w=7, h=10)
dendro_mag_plot 
# dev.off()7.3 Make pie charts to represent core location of each MAG
mag_pie_order <- rev(labeled_dendro_order)7.4 By region only
Prepare data frame and factor.
region_mags_df <- mag_tpm_location %>%
replace_na(list(mag_tpm=0)) %>%
group_by(REGION, mag) %>%
summarise(mag_sum_tpm = sum(mag_tpm))## `summarise()` has grouped output by 'REGION'. You can override using the `.groups` argument.region_order <- c("IO","MS","NAO","NPO","SAO","SO","SPO","RS")
region_color <- c("#711518", "#ce536b", "#c76b4a", "#dfa837", "#93b778", "#61ac86", "#657abb", "#67765b")
region_mags_df$REGION_ORDER <- factor(region_mags_df$REGION, levels = region_order)
region_mags_df$MAG_ORDER <- factor(region_mags_df$mag, levels = mag_pie_order)
names(region_color) <- region_order
# View(region_dictyo)Plot pies by region
region_mag <- region_mags_df %>%
add_column(fake = "fake") %>%
ggplot(aes(x = fake, fill = REGION_ORDER, y = mag_sum_tpm)) +
geom_bar(color = "white", stat = "identity", position = "fill") +
scale_fill_manual(values = region_color) +
# theme_linedraw() +
coord_polar(theta = "y") +
# coord_flip() +
facet_wrap(~MAG_ORDER, ncol = 1) +
# scale_y_continuous(expand = c(0,0)) +
theme_void() +
theme(legend.title = element_blank(),
strip.text = element_text(size = 3),
# plot.margin = element_blank(),
plot.background = element_blank()) +
labs(y = "MAG Abundance TPM", x = "Putative Dictyochophyte MAGs") #+
# theme(strip.text = element_text(size = rel(3.0), vjust = -4.0),
# panel.margin.y = unit(-2, "lines"))
# region_mag7.5 By depth
Prepare data frame and factor.
depth_mags_df <- mag_tpm_location %>%
replace_na(list(mag_tpm=0)) %>%
group_by(DEPTH, mag) %>%
summarise(mag_sum_tpm = sum(mag_tpm))## `summarise()` has grouped output by 'DEPTH'. You can override using the `.groups` argument.depth_order <- c("DCM", "FSW", "SRF", "MIX", "MES", "ZZZ")
depth_color <- c("#74a9cf", "#969696", "#d0d1e6", "#0570b0", "#023858", "#252525")
depth_mags_df$DEPTH_ORDER <- factor(depth_mags_df$DEPTH, levels = depth_order)
depth_mags_df$MAG_ORDER <- factor(depth_mags_df$mag, levels = mag_pie_order)
names(depth_color) <- depth_order
# View(depth_dictyo)Plot pies by depth
depth_mag <- depth_mags_df %>%
add_column(fake = "fake") %>%
ggplot(aes(x = fake, fill = DEPTH_ORDER, y = mag_sum_tpm)) +
geom_bar(color = "white", stat = "identity", position = "fill") +
scale_fill_manual(values = depth_color) +
# theme_linedraw() +
coord_polar(theta = "y") +
# coord_flip() +
facet_wrap(~MAG_ORDER, ncol = 1) +
# scale_y_continuous(expand = c(0,0)) +
theme_void() +
theme(legend.title = element_blank(),
strip.text = element_text(size = 4)) +
labs(y = "MAG Abundance TPM", x = "Putative Dictyochophyte MAGs")7.6 By size fraction
Prepare data frame and factor.
frac_mags_df <- mag_tpm_location %>%
replace_na(list(mag_tpm=0)) %>%
group_by(SIZEFRAC, mag) %>%
summarise(mag_sum_tpm = sum(mag_tpm))## `summarise()` has grouped output by 'SIZEFRAC'. You can override using the `.groups` argument.frac_order <- c("0.8-5.00", "5-20.00", "20-180.00", "180-2000.00")
frac_color <- c("#f7fcb9", "#addd8e", "#41ab5d", "#004529")
frac_mags_df$FRAC_ORDER <- factor(frac_mags_df$SIZEFRAC, levels = frac_order)
frac_mags_df$MAG_ORDER <- factor(frac_mags_df$mag, levels = mag_pie_order)
names(frac_color) <- frac_order
# View(frac_dictyo)Plot pies by size fraction
frac_mag <- frac_mags_df %>%
add_column(fake = "fake") %>%
ggplot(aes(x = fake, fill = FRAC_ORDER, y = mag_sum_tpm)) +
geom_bar(color = "white", stat = "identity", position = "fill") +
scale_fill_manual(values = frac_color) +
# theme_linedraw() +
coord_polar(theta = "y") +
# coord_flip() +
facet_wrap(~MAG_ORDER, ncol = 1) +
# scale_y_continuous(expand = c(0,0)) +
theme_void() +
theme(legend.title = element_blank(),
strip.text = element_text(size = 4)) +
labs(y = "MAG Abundance TPM", x = "Putative Dictyochophyte MAGs")7.7 Bubble plot to show rel abun of each MAG
Prepare data frame and factor.
head(mag_tpm_location)## # A tibble: 6 x 7
## # Groups: mag, DEPTH, REGION [2]
## mag SAMPLE DEPTH REGION SIZEFRAC mag_tpm log_mag_tpm
## <fct> <chr> <chr> <chr> <chr> <dbl> <dbl>
## 1 TOPAZ_IOS1_E045 IO DCM 0.8-5.00 DCM IO 0.8-5.00 8598. 9.06
## 2 TOPAZ_IOS1_E045 IO DCM 180-2000.00 DCM IO 180-2000.… 2176. 7.69
## 3 TOPAZ_IOS1_E045 IO DCM 20-180.00 DCM IO 20-180.00 3185. 8.07
## 4 TOPAZ_IOS1_E045 IO DCM 5-20.00 DCM IO 5-20.00 162. 5.09
## 5 TOPAZ_IOS1_E045 MS DCM 0.8-5.00 DCM MS 0.8-5.00 1648. 7.41
## 6 TOPAZ_IOS1_E045 MS DCM 180-2000.00 DCM MS 180-2000.… 1950. 7.58total_relabun_mag <- mag_tpm_location %>%
replace_na(list(mag_tpm=0)) %>%
group_by(mag) %>%
summarise(mag_sum_tpm = sum(mag_tpm))
total_relabun_mag$MAG_ORDER <- factor(total_relabun_mag$mag, levels = mag_pie_order)rel_abun <- total_relabun_mag %>%
add_column(fake = "fake") %>%
ggplot(aes(x = fake, size = mag_sum_tpm, y = mag)) +
geom_point(color = "black") +
scale_size_continuous(range = c(1, 17)) +
facet_wrap(~MAG_ORDER, ncol = 1) +
# scale_y_continuous(expand = c(0,0)) +
theme_void() +
theme(legend.title = element_blank(),
strip.text = element_text(size = 4))Compiled plots. Same order as the dendrogram above, so these pie charts can be lined up with the dendrogram.
# svg("pies-mag-abun-withoutlabels.svg", h = 20, w = 15)
# plot_grid(region_mag, depth_mag, frac_mag, rel_abun, nrow = 1)
plot_grid(region_mag + theme(strip.text = element_text(size = rel(3.0), vjust = -4.0),
panel.margin.y = unit(-2, "lines")),
depth_mag+ theme(strip.text = element_text(size = rel(3.0), vjust = -4.0),
panel.margin.y = unit(-2, "lines")),
frac_mag+ theme(strip.text = element_text(size = rel(3.0), vjust = -4.0),
panel.margin.y = unit(-2, "lines")),
rel_abun,
nrow = 1)## Warning: `panel.margin` is deprecated. Please use `panel.spacing` property
## instead
## Warning: `panel.margin` is deprecated. Please use `panel.spacing` property
## instead
## Warning: `panel.margin` is deprecated. Please use `panel.spacing` property
## instead
## Warning: `panel.margin` is deprecated. Please use `panel.spacing` property
## instead
## Warning: `panel.margin` is deprecated. Please use `panel.spacing` property
## instead
## Warning: `panel.margin` is deprecated. Please use `panel.spacing` property
## instead
# dev.off()7.8 Intersection of transcripts
First, incorporate KEGG module information into mapped metatranscriptome data.
keggs_to_match <- select(metaT_mapped, KO) %>% distinct()
# head(keggs_to_match)Import provided KEGG information (module information) and list of KEGG IDs selected to model trophic mode.
kegg_vita <- read.csv("../data/vita_vars.csv")
load(file = "../data/KEGG-key.RData", verbose = TRUE)## Loading objects:
## kegg
## K0_gene_wModskegg_key_dictyo <- keggs_to_match %>%
left_join(kegg_vita %>% add_column(VITA = "vita"), by = c("KO" = "Selected.KOs")) %>%
left_join(kegg, by = c("KO" = "KO_number")) %>%
data.frame
# head(kegg_key_dictyo)
# dim(keggs_to_match);dim(kegg_key_dictyo)Supplementary figure showing shared and unique metatranscriptome reads among selected MAGs.
# pdf("../si-figures/SI-SAR-Dictyocho-MAG-KEGG-intersection.pdf", w = 15, h = 15)
metaT_mapped_trophy %>%
type.convert(as.is = TRUE) %>%
pivot_longer(cols = starts_with("ERR"), names_to = "SAMPLEID", values_to = "transcript_tpm") %>%
left_join(kegg_key_dictyo %>% select(KO, B) %>% distinct()) %>%
group_by(MAG, KO, B) %>%
summarise(transcript_tpm_sum = sum(transcript_tpm)) %>%
ungroup() %>%
group_by(KO, B) %>%
summarise(transcript_to_mag = list(MAG)) %>%
ggplot(aes(transcript_to_mag)) +
# geom_bar(color = "black", fill = "#AC7070", width = 0.7) +
geom_bar(color = "black", width = 0.7, aes(fill = B)) +
scale_fill_brewer(palette = "Dark2") +
scale_x_upset(order_by = "freq",
n_intersections = 30, position = "top") +
scale_y_continuous(expand = c(0,0)) +
theme_classic() +
theme_combmatrix(combmatrix.label.text = element_text(color = "black", size = 14),
combmatrix.label.extra_spacing = 10) +
theme(axis.text = element_text(color = "black", face = "bold", size = 12),
legend.title = element_blank()) +
labs(x = "Frequency across MAGs",
y = "Shared transcripts",
title = "Metatranscriptome reads that mapped to dictyochophyte MAGs")## Joining, by = "KO"## `summarise()` has grouped output by 'MAG', 'KO'. You can override using the `.groups` argument.## `summarise()` has grouped output by 'KO'. You can override using the `.groups` argument.## Warning: Removed 3805 rows containing non-finite values (stat_count).
# dev.off()7.9 Subset categories to look at shared metabolic potential
Categories to obtain from the MAGs: * Phototrophy-exclusive: Among the phototrophy-predicted MAGs, what KEGG IDs are present in any of the phototrophy-predicted MAGs and absent from the heterotrophy MAGs? * Phototrophy-core: What KEGG IDs are present in ALL (shared in all MAGs) phototrophy-predicted MAGs? (regardless of presence in heterotrophy-predicted MAGs) * Heterotrophy-exclusive: Among the heterotrophy-predicted MAGs, what KEGG IDs are present in any of the heterotrophy MAGs and absent from the phototrophy MAGs? * Heterotrophy-core: What KEGG IDs are shared in ALL heterotrophy-predicted MAGs? (regardless of presence in phototrophy-predicted MAGs) * Core across trophic strategy: What KEGG IDs are found in both heterotrophy and phototrophy MAGs? KEGG IDs must be found in both sets of MAGs at least once. * Core shared transcripts: What KEGG IDs are shared among ALL MAGs? (PCA analysis too) * PCA analysis with vita-selected KEGG IDs
# Get list of phototrophy predicted MAGs
tmp <- metaT_mapped_trophy %>%
filter(PredictedTrophicMode == "Phototroph")
photo_mags <- as.character(unique(tmp$MAG))
tmp2 <- metaT_mapped_trophy %>%
filter(PredictedTrophicMode != "Phototroph")
hetero_mags <- as.character(unique(tmp2$MAG))
# Take stock
length(photo_mags) # n=11## [1] 11length(hetero_mags) # n=13## [1] 13Set up data frame to sub-sample specific groupings.
classify_keggs <- metaT_mapped %>%
select(-starts_with("ERR")) %>%
add_column(value = 1) %>%
pivot_wider(names_from = MAG, values_from = value, values_fill = NA)
# head(classify_keggs)Phototrophy-exclusive: Among the phototrophy-predicted MAGs, what KEGG IDs are present in any of the phototrophy-predicted MAGs and absent from the heterotrophy MAGs? Also determine how many KEGG ids are present in all of the MAGs, only found in 1, and in at least 2.
# Phototrophy-exclusive
num_mags_photo <- length(photo_mags)
photo_excl <- classify_keggs %>%
filter_at(all_of(hetero_mags), all_vars(is.na(.))) %>%
# select(photo_mags) %>% # Should be sporadically 1s
# select(hetero_mags) %>% #should all be NAs
select(KO, photo_mags) %>% column_to_rownames(var = "KO") %>%
# Document number of times KOs appears across MAGs
mutate(present = (rowSums(!is.na(.)))) %>%
mutate(Photo_excl_class = case_when(
present == num_mags_photo ~ "All MAGs",
present == 1 ~ "Only 1 MAG",
present >= 2 ~ "At least 2 MAGs"
)) %>% rownames_to_column(var = "KO") %>%
select(KO, Photo_excl_class) %>% distinct() %>%
add_column(Phototrophy_exclusive = "photo-excl")## Note: Using an external vector in selections is ambiguous.
## ℹ Use `all_of(photo_mags)` instead of `photo_mags` to silence this message.
## ℹ See <https://tidyselect.r-lib.org/reference/faq-external-vector.html>.
## This message is displayed once per session.# head(photo_excl)
# length(unique(photo_excl$KO))Phototrophy-core: What KEGG IDs are present in ALL (shared in all MAGs) phototrophy-predicted MAGs? (regardless of presence in heterotrophy-predicted MAGs)
# Phototrophy-core
num_mags_photo <- length(photo_mags)
photo_core <- classify_keggs %>%
filter_at(all_of(photo_mags), all_vars(!is.na(.))) %>%
# select(photo_mags) %>% # Should all be 1s
# select(hetero_mags) #%>% # Should be/can be sporadic
select(KO, photo_mags) %>% column_to_rownames(var = "KO") %>%
# Document number of times KOs appears across MAGs
mutate(present = (rowSums(!is.na(.)))) %>%
mutate(Photo_core_class = case_when(
present == num_mags_photo ~ "All MAGs",
present == 1 ~ "Only 1 MAG",
present >= 2 ~ "At least 2 MAGs"
)) %>% rownames_to_column(var = "KO") %>%
select(KO, Photo_core_class) %>% distinct() %>%
add_column(Phototrophy_core = "photo-core")
# head(photo_core)
# dim(photo_core)Heterotrophy-exclusive: Among the heterotrophy-predicted MAGs, what KEGG IDs are present in any of the heterotrophy MAGs and absent from the phototrophy MAGs? And determine the KEGGs that appear in all MAGs, only 1, and in at least 2.
# Heterotrophy-exclusive
num_mags_hetero <- length(hetero_mags)
# head(classify_keggs)
hetero_excl <- classify_keggs %>%
filter_at(all_of(photo_mags), all_vars(is.na(.))) %>%
# select(photo_mags) %>% # Should all be NA
# select(hetero_mags) %>% # Should/can be sporadically 1
# head
select(KO, hetero_mags) %>% column_to_rownames(var = "KO") %>%
# Document number of times KOs appears across MAGs
mutate(present = (rowSums(!is.na(.)))) %>%
mutate(Het_excl_class = case_when(
present == num_mags_hetero ~ "All MAGs",
present == 1 ~ "Only 1 MAG",
present >= 2 ~ "At least 2 MAGs"
)) %>% rownames_to_column(var = "KO") %>%
select(KO, Het_excl_class) %>% distinct() %>%
add_column(Heterotrophy_exclusive = "het-excl")## Note: Using an external vector in selections is ambiguous.
## ℹ Use `all_of(hetero_mags)` instead of `hetero_mags` to silence this message.
## ℹ See <https://tidyselect.r-lib.org/reference/faq-external-vector.html>.
## This message is displayed once per session.# dim(hetero_excl)
# head(hetero_excl)Heterotrophy-core: What KEGG IDs are shared in ALL heterotrophy-predicted MAGs? (regardless of presence in phototrophy-predicted MAGs)
# Heterotrophy-core
num_mags_hetero <- length(hetero_mags)
hetero_core <- classify_keggs %>%
filter_at(all_of(hetero_mags), all_vars(!is.na(.))) %>%
# select(photo_mags) #%>% # Should/can be sporadically 1
# select(hetero_mags) %>% # Should all be 1
# head
select(KO, hetero_mags) %>% column_to_rownames(var = "KO") %>%
mutate(present = (rowSums(!is.na(.)))) %>%
mutate(Het_core_class = case_when(
present == num_mags_hetero ~ "All MAGs",
present == 1 ~ "Only 1 MAG",
present >= 2 ~ "At least 2 MAGs"
)) %>% rownames_to_column(var = "KO") %>%
select(KO, Het_core_class) %>% distinct() %>%
add_column(Heterotrophy_core = "het-core")
# head(hetero_core)Core across trophic strategy (across trophy): What KEGG IDs are found in both heterotrophy and phototrophy MAGs? KEGG IDs must be found in both sets of MAGs at least once. Core shared transcripts (shared MAGs): What KEGG IDs are shared among ALL MAGs? (PCA analysis too)
# Core across trophic strategy
## Must appear at least once in PHOTO and HETERO lists
num_all_mags <- num_mags_hetero + num_mags_photo
# num_all_mags
# tmp <- classify_keggs %>%
across_trophy <- classify_keggs %>%
filter_at(vars(hetero_mags), any_vars(!is.na(.))) %>%
filter_at(vars(photo_mags), any_vars(!is.na(.))) %>%
# select(photo_mags) %>% # Should/can be sporadically 1
# select(hetero_mags) %>% # Should/can be sporadically 1
column_to_rownames(var = "KO") %>%
mutate(present = (rowSums(!is.na(.)))) %>%
mutate(Trophy_core_class = case_when(
present == num_all_mags ~ "All MAGs",
present == 1 ~ "Only 1 MAG",
present >= 2 ~ "At least 2 MAGs"
)) %>% rownames_to_column(var = "KO") %>%
select(KO, Trophy_core_class) %>% distinct() %>%
add_column(Across_trophy= "core-across")
# Should be zero for both instances
# tmp_result <- tmp %>%
# filter_at(vars(photo_mags), all_vars(is.na(.)))
# # filter_at(vars(hetero_mags), all_vars(is.na(.)))
# head(tmp_result)
# Core shared transcripts: no NAs listed under any MAG
shared_allmags <- classify_keggs %>%
filter_at(vars(starts_with("TOPAZ")), all_vars(!is.na(.))) %>%
column_to_rownames(var = "KO") %>%
mutate(present = (rowSums(!is.na(.)))) %>%
mutate(All_shared_class = case_when(
present == num_all_mags ~ "All MAGs",
present == 1 ~ "Only 1 MAG",
present >= 2 ~ "At least 2 MAGs"
)) %>% rownames_to_column(var = "KO") %>%
select(KO, All_shared_class) %>% distinct() %>%
add_column(Shared_MAGs = "shared-all")
# table(shared_allmags$All_shared_class)Take stock in the KEGG ID lists generated, join all and explore.
kegg_classification_all <- shared_allmags %>%
full_join(across_trophy) %>%
full_join(hetero_core) %>%
full_join(hetero_excl) %>%
full_join(photo_core) %>%
full_join(photo_excl)## Joining, by = "KO"
## Joining, by = "KO"
## Joining, by = "KO"
## Joining, by = "KO"
## Joining, by = "KO"head(kegg_classification_all)## KO All_shared_class Shared_MAGs Trophy_core_class Across_trophy
## 1 K00029 All MAGs shared-all All MAGs core-across
## 2 K00249 All MAGs shared-all All MAGs core-across
## 3 K00326 All MAGs shared-all All MAGs core-across
## 4 K00472 All MAGs shared-all All MAGs core-across
## 5 K00799 All MAGs shared-all All MAGs core-across
## 6 K00873 All MAGs shared-all All MAGs core-across
## Het_core_class Heterotrophy_core Het_excl_class Heterotrophy_exclusive
## 1 All MAGs het-core <NA> <NA>
## 2 All MAGs het-core <NA> <NA>
## 3 All MAGs het-core <NA> <NA>
## 4 All MAGs het-core <NA> <NA>
## 5 All MAGs het-core <NA> <NA>
## 6 All MAGs het-core <NA> <NA>
## Photo_core_class Phototrophy_core Photo_excl_class Phototrophy_exclusive
## 1 All MAGs photo-core <NA> <NA>
## 2 All MAGs photo-core <NA> <NA>
## 3 All MAGs photo-core <NA> <NA>
## 4 All MAGs photo-core <NA> <NA>
## 5 All MAGs photo-core <NA> <NA>
## 6 All MAGs photo-core <NA> <NA># Kegg IDs appear once in this data frame.
# dim(kegg_classification_all); length(unique(kegg_classification_all$KO))plot_bar_categories <- kegg_classification_all %>%
pivot_longer(cols = -c(KO, ends_with("_class"))) %>%
mutate(Class = case_when(
name == "Heterotrophy_exclusive" ~ Het_excl_class,
name == "Phototrophy_exclusive" ~ Photo_excl_class,
name == "Heterotrophy_core" ~ Het_core_class,
name == "Phototrophy_core" ~ Photo_core_class,
name == "Across_trophy" ~ Trophy_core_class,
name == "Shared_MAGs" ~ All_shared_class,
TRUE ~ "Else"
)) %>%
filter(!is.na(value)) %>%
left_join(kegg_key_dictyo %>% select(KO, B) %>% distinct()) %>%
type.convert(as.is = TRUE) %>%
mutate(Kegg_module = case_when(
is.na(B) ~ "Not annotated",
TRUE ~ B
)) %>%
pivot_longer(cols = c(Kegg_module, Class), names_to = "Fill_type", values_to = "Fill_class") %>%
data.frame## Joining, by = "KO"## FACTORIZATION
a <- plot_bar_categories %>% filter(Fill_type == "Class") %>% select(Fill_class) %>% distinct()
class_order <- as.character(unique(a$Fill_class))
class_greys <- c("#525252", "#969696", "#cccccc")
kegg_order <- c("Energy metabolism", "Carbohydrate and lipid metabolism", "Nucleotide and amino acid metabolism", "Metabolism", "Environmental information processing", "Genetic information processing", "Secondary metabolism", "Gene set","Not annotated")
kegg_color <- c("#e41a1c","#377eb8","#4daf4a","#984ea3","#ff7f00","#ffff33","#a65628","#f0f0f0")
# unique(plot_bar_categories$Fill_class)
plot_bar_categories$FILL_CLASS_ORDER <- factor(plot_bar_categories$Fill_class, levels = c(class_order, kegg_order))
all_colors <- c(class_greys, kegg_color)# Final ggplot
# svg("panel-barplots-bycategory.svg", h = 6, w = 8)
plot_grid(
plot_bar_categories %>%
filter(name != "Across_trophy") %>%
ggplot(aes(x = Fill_type, fill = FILL_CLASS_ORDER)) +
geom_bar(stat = "count", aes(fill = FILL_CLASS_ORDER), color = "black", width = 0.6) +
scale_fill_manual(values = all_colors) +
facet_grid(vars(name),
space = "free", scales = "free") +
coord_flip() +
theme_bw() +
scale_y_continuous(expand = c(0, 0), limits = c(0, 650), breaks = c(seq(from = 0, to = 800, by = 100))) +
theme(legend.title = element_blank(),
axis.text.x = element_text(size = 12, color = "black"),
strip.background = element_blank(),
strip.placement = "outside",
strip.text.y = element_text(angle = 0, hjust = 0, vjust = 0.5),
axis.text.y = element_blank(),
axis.ticks.y = element_blank()) +
labs(x = "", y = "Number of Keggs"),
plot_bar_categories %>%
filter(name == "Across_trophy") %>%
ggplot(aes(x = Fill_type, fill = FILL_CLASS_ORDER)) +
geom_bar(stat = "count", aes(fill = FILL_CLASS_ORDER), color = "black", width = 0.6) +
scale_fill_manual(values = all_colors) +
facet_grid(vars(name),
space = "free", scales = "free") +
coord_flip() +
theme_bw() +
scale_y_continuous(expand = c(0, 0), limits = c(0,3500)) +
theme(legend.title = element_blank(),
axis.text.x = element_text(size = 12, color = "black"),
strip.background = element_blank(),
strip.placement = "outside",
strip.text.y = element_text(angle = 0, hjust = 0, vjust = 0.5),
axis.text.y = element_blank(),
axis.ticks.y = element_blank(),
legend.position = "none",
panel.grid = element_blank()) +
labs(x = "", y = "Number of orthologs"),
ncol = 1, axis = c("lr"), align = c("vh"),
rel_heights = c(1, 0.3))
# dev.off()7.10 Metatranscriptome analysis - ordination plots
7.11 Explore ordination based on the shared KEGGs across all MAGs
Isolate and conduct PCA analysis with orthologs that appear in all 24 MAGs only
pca_shared_all <- pca_make_df(metaT_mapped_trophy, shared_allmags)## Joining, by = "run_accession"## `summarise()` has grouped output by 'MAG', 'KO', 'REGION', 'DEPTH', 'SIZEFRAC'. You can override using the `.groups` argument.## Joining, by = "run_accession"
# pca_across_trophic <- pca_make_df(metaT_mapped_trophy, across_trophy)
# pca_across_hetero_core <- pca_make_df(metaT_mapped_trophy, hetero_core)
# pca_across_hetero_excl <- pca_make_df(metaT_mapped_trophy, hetero_excl)
# pca_across_photo_core <- pca_make_df(metaT_mapped_trophy, photo_core)
# pca_across_photo_excl <- pca_make_df(metaT_mapped_trophy, photo_excl)Explore PCA plotting options
pca_madness(pca_shared_all)
# svg("pca-shared-trophymode.svg", h = 7, w = 9)
pca_shared_all %>%
ggplot(aes(x = PC1, y = PC2, size = HeterotrophyScore, fill = PredictedTrophicMode)) +
geom_point(aes(fill = PredictedTrophicMode), shape = 21,
# geom_point(aes(fill = HeterotrophyScore,
# shape = PredictedTrophicMode), size = 2,
stroke = 0.6) +
scale_size_binned(nice.breaks = TRUE, n.breaks = 12, range = c(0.4,8)) +
# scale_size_continuous(range = c(0.5, 7)) +
theme_bw() +
# scale_color_gradient2(low = "#B4CC3D",
# mid = "white",
# high = "#CC3D6D",
# midpoint = 0,
# breaks = c(-200,-100, -50, 0, 50, 100)) +
scale_fill_manual(values = c("#CC3D6D","#B4CC3D")) +
# scale_shape_manual(values = c(22,23)) +
theme(axis.text = element_text(size = 10, color = "black"))
# dev.off()Supplementary plot
# pdf("../si-figures/SI-SAR-Dictyocho-PCA-byMAG.pdf", h = 8, w = 12)
pca_shared_all %>%
ggplot(aes(x = PC1, y = PC2, size = HeterotrophyScore, fill = MAG)) +
geom_point(aes(fill = MAG), shape = 21,
# geom_point(aes(fill = HeterotrophyScore,
# shape = PredictedTrophicMode), size = 2,
stroke = 0.6) +
scale_size_binned(nice.breaks = TRUE, n.breaks = 8, range = c(0.4,8)) +
# scale_size_continuous(range = c(0.5, 7)) +
theme_bw() +
# scale_color_gradient2(low = "#B4CC3D",
# mid = "white",
# high = "#CC3D6D",
# midpoint = 0,
# breaks = c(-200,-100, -50, 0, 50, 100)) +
# scale_fill_manual(values = c("#CC3D6D","#B4CC3D")) +
scale_fill_manual(values = c("#a6cee3","#1f78b4","#b2df8a","#33a02c","#fb9a99","#e31a1c","#fdbf6f","#ff7f00","#cab2d6","#6a3d9a","#ffff99","#b15928","#8dd3c7","#ffffb3","#bebada","#fb8072","#80b1d3","#fdb462","#b3de69","#fccde5","#d9d9d9","#bc80bd","#ccebc5","#ffed6f")) +
# scale_shape_manual(values = c(22,23)) +
theme(axis.text = element_text(size = 10, color = "black")) + guides(fill = guide_legend(ncol = 2))
# dev.off()7.11.1 3-D PCA analysis
7.12 Isolate genes of interest
Subset genes that are more prominent in certain categories. While the intention is to isolate genes that may be indicative of a more phototrophic versus heterotrophic lifestyle, it is likely that there will be a gene suite that is more prominent in one of those categories. BUT as a whole, analysis of all the genes will be the most appropriate avenue for determining potential trophic strategies.
subset_mapped_transcripts <- metaT_mapped_trophy %>%
type.convert(as.is = TRUE) %>%
pivot_longer(cols = starts_with("ERR"), names_to = "run_accession", values_to = "transcript_tpm") %>%
# Remove zero counts
filter(transcript_tpm > 0) %>%
# Remove Kegg IDs with no information
filter(KO != "NoKID") %>%
# Add annotation information
left_join(kegg_key_dictyo %>% select(KO, Gene_identification, VITA, B, C) %>% distinct()) %>%
# Remove genes with no protein ID
filter(!is.na(Gene_identification)) %>%
# Select only VITA chosen KEGG IDs
filter(VITA == "vita") %>%
# Join with metadata
left_join(metaT_reformat) %>%
unite(col = "Annotation", KO, Gene_identification, sep = " ", remove = FALSE) %>%
# summarise:
group_by(MAG, Annotation, KO, PredictedTrophicMode, HeterotrophyScore, Gene_identification, B, C) %>%
summarise(SUM = sum(transcript_tpm)) %>%
data.frame## Joining, by = "KO"## Joining, by = "run_accession"## `summarise()` has grouped output by 'MAG', 'Annotation', 'KO', 'PredictedTrophicMode', 'HeterotrophyScore', 'Gene_identification', 'B'. You can override using the `.groups` argument.# head(subset_mapped_transcripts)
# 554 different annotations
# option to save dataframe
# save(subset_mapped_transcripts, photo_excl, photo_core, hetero_excl, hetero_core, shared_allmags, across_trophy, file = "../data/MAG-casestudy-Stramenopile-mappedmetaT-categories.RData")Of those subset genes, how many belong to the various categories?
generate_list_keggs <- function(df, query){
query_list <- as.character(unique(query$KO))
df_out <- df %>%
filter(KO %in% query_list)
print(length(unique(df_out$Annotation)))
return(df_out)
}
photo_E <- generate_list_keggs(subset_mapped_transcripts, photo_excl) #123## [1] 123photo_C <- generate_list_keggs(subset_mapped_transcripts, photo_core) #29## [1] 29het_E <- generate_list_keggs(subset_mapped_transcripts, hetero_excl) #90## [1] 90het_C <- generate_list_keggs(subset_mapped_transcripts, hetero_core) #27## [1] 27shared_ALL <- generate_list_keggs(subset_mapped_transcripts, shared_allmags) #9## [1] 9across_TROPHY <- generate_list_keggs(subset_mapped_transcripts, across_trophy) #341## [1] 341Plot comparisons
# head(photo_E)
# Factor MAG list so it is in order of heterotrophy score
plot_bymag <- function(df, occur){
# Make tmp dataframe and factor MAG x-axis by heterotrophy score
mag_list_tmp <- df %>%
select(MAG, HeterotrophyScore) %>% distinct()
mag_ordered <- (mag_list_tmp$MAG)[order(mag_list_tmp$HeterotrophyScore)]
# make a new df with occurence information
df_revised <- df %>%
# Group by annotation and MAG, remove rows if there is an NA and it is duplicated
group_by(Annotation, MAG) %>%
filter_at(vars(Annotation), any_vars(!duplicated(.)|is.na(.))) %>%
ungroup() %>%
group_by(Annotation) %>%
mutate(OCCUR = n_distinct(MAG)) %>%
filter(OCCUR >= occur)
# make tmp dataframe and factor annotation y-axis by occurence
annot_list_tmp <- df_revised %>%
select(Annotation, OCCUR) %>% distinct()
annot_order <- (annot_list_tmp$Annotation)[order(annot_list_tmp$OCCUR)]
# Factor revised dataframe
df_revised$MAG_order <- factor(df_revised$MAG, levels = rev(mag_ordered))
df_revised$ANNOT_order <- factor(df_revised$Annotation, levels = rev(annot_order))
ggplot(df_revised, aes(x = MAG_order, y = ANNOT_order, size = log(SUM), fill = HeterotrophyScore)) +
geom_point(shape = 21, aes(fill=HeterotrophyScore)) +
scale_fill_gradient2(low = "#B4CC3D",
mid = "white",
high = "#CC3D6D",
midpoint = 0,
breaks = c(-200,-100, -50, 0, 50, 100)) +
scale_size_continuous(range = c(0,7)) +
theme_half_open() +
facet_grid(C~PredictedTrophicMode, space = "free", scales = "free") +
theme(axis.text.x = element_text(angle = 45, vjust = 1, hjust = 1, size = 10),
axis.text.y = element_text(size = 10),
strip.background = element_blank(),
strip.text.y = element_text(angle = 0, size = 7, hjust = 0, vjust = 0.5),
plot.title = element_text(size = 8)) +
labs(title = "Transcripts expressed by MAG\nSelected KEGGs = vita-selected & MAG distribution")
}# svg("photo_excl_bubble.svg", w = 12, h = 16)
plot_bymag(photo_E, 6)
# dev.off()# svg("photo_core_bubble.svg", w = 14, h = 10)
plot_bymag(photo_C, 6)
# dev.off()# svg("het_core_bubble.svg", w = 15, h = 8)
plot_bymag(het_C, 6)
# dev.off()# svg("het_excl_bubble.svg", w = 13, h = 15)
plot_bymag(het_E, 6)
# dev.off()# svg("across_bubble.svg", w = 18, h = 40)
plot_bymag(across_TROPHY, 11)
# dev.off()# svg("shared-ALL_bubble.svg", w = 14, h = 6)
plot_bymag(shared_ALL, 5)
# dev.off()7.13 Subset vita-selected genes - heatmap by sample
An untargetted approach up to this point has distilled down the list of genes. Continue exploring differences in the metatranscriptome expression profile across MAGs.
Option to load from previous data.
# load("../data/MAG-casestudy-Stramenopile-mappedmetaT-categories.RData", verbose = TRUE)Select the vita-associated IDs.
head(subset_mapped_transcripts)## MAG
## 1 TOPAZ_IOS1_E045
## 2 TOPAZ_IOS1_E045
## 3 TOPAZ_IOS1_E045
## 4 TOPAZ_IOS1_E045
## 5 TOPAZ_IOS1_E045
## 6 TOPAZ_IOS1_E045
## Annotation
## 1 K00003 E1.1.1.3; homoserine dehydrogenase
## 2 K00003 E1.1.1.3; homoserine dehydrogenase
## 3 K00010 iolG; myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase [EC:1.1.1.18 1.1.1.369]
## 4 K00033 PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase
## 5 K00036 G6PD, zwf; glucose-6-phosphate 1-dehydrogenase
## 6 K00053 ilvC; ketol-acid reductoisomerase
## KO PredictedTrophicMode HeterotrophyScore
## 1 K00003 Phototroph -179
## 2 K00003 Phototroph -179
## 3 K00010 Phototroph -179
## 4 K00033 Phototroph -179
## 5 K00036 Phototroph -179
## 6 K00053 Phototroph -179
## Gene_identification
## 1 E1.1.1.3; homoserine dehydrogenase
## 2 E1.1.1.3; homoserine dehydrogenase
## 3 iolG; myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase [EC:1.1.1.18 1.1.1.369]
## 4 PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase
## 5 G6PD, zwf; glucose-6-phosphate 1-dehydrogenase
## 6 ilvC; ketol-acid reductoisomerase
## B C
## 1 Nucleotide and amino acid metabolism Cysteine and methionine metabolism
## 2 Nucleotide and amino acid metabolism Serine and threonine metabolism
## 3 <NA> <NA>
## 4 Carbohydrate and lipid metabolism Central carbohydrate metabolism
## 5 Carbohydrate and lipid metabolism Central carbohydrate metabolism
## 6 Nucleotide and amino acid metabolism Branched-chain amino acid metabolism
## SUM
## 1 30569.547
## 2 30569.547
## 3 2369.379
## 4 2396.429
## 5 9251.762
## 6 14932.282# length(unique(subset_mapped_transcripts$Annotation))
vita_only <- subset_mapped_transcripts %>%
select(MAG, KO, SUM) %>% distinct() %>%
pivot_wider(id_cols = MAG, names_from = KO,
values_from = SUM, values_fill = 0) %>%
column_to_rownames(var = "MAG")# Annotation
annot_mag <- subset_mapped_transcripts %>%
select(MAG, PredictedTrophicMode) %>% distinct() %>%
column_to_rownames(var = "MAG")
rownames(annot_mag) <- rownames(vita_only)
unique(annot_mag$PredictedTrophicMode)## [1] "Phototroph" "Heterotroph"annot_color = list(PredictedTrophicMode = c(Phototroph = "#B4CC3D", Heterotroph = "#CC3D6D"))pheatmap(vita_only,
annotation_row = annot_mag,
annotation_colors = annot_color,
annotation_names_row = FALSE,
scale = "column",
cluster_cols = TRUE,
cluster_rows = TRUE,
clustering_distance_rows = "correlation",
show_colnames = FALSE)
# ?pheatmap()7.14 Isolate specific gene sets
Option to load from previous data.
# load("../data/MAG-casestudy-Stramenopile-mappedmetaT-categories.RData", verbose = TRUE)
# subset_mapped_transcripts == vita selected only kegg IDsFilter by occurrence and size.
# head(photo_C); head(het_C)
photo_c_list <- as.character(unique(photo_core$KO));length(photo_c_list)## [1] 148het_c_list <- as.character(unique(hetero_core$KO));length(het_c_list)## [1] 181shared <- as.character(unique(shared_allmags$KO));length(shared)## [1] 49# head(subset_mapped_transcripts)
subset_vita_target <- subset_mapped_transcripts %>%
select(MAG, Annotation, KO, PredictedTrophicMode, HeterotrophyScore, SUM) %>%
filter(KO %in% photo_c_list | KO %in% het_c_list | KO %in% shared) %>%
# Group by annotation and MAG, remove rows if there is an NA and it is duplicated
group_by(Annotation, MAG) %>%
filter_at(vars(Annotation), any_vars(!duplicated(.)|is.na(.))) %>%
ungroup() %>%
group_by(Annotation) %>%
mutate(OCCUR = n_distinct(MAG)) %>%
filter(OCCUR >= 11 & OCCUR < 22) # between 50-75%
length(unique(subset_vita_target$KO))## [1] 26# View(subset_vita_target)
# Target gene set:
kegg_set <- as.character(unique(subset_vita_target$KO))Pheatmap with target gene set:
# length(unique(subset_mapped_transcripts$Annotation))
targetgene_26_byMAG <- subset_mapped_transcripts %>%
filter(KO %in% kegg_set) %>%
select(MAG, Annotation, SUM) %>% distinct() %>%
pivot_wider(id_cols = MAG, names_from = Annotation,
values_from = SUM, values_fill = 0) %>%
column_to_rownames(var = "MAG")
# dim(targetgene_26_byMAG)# Annotation
annot_mag <- subset_mapped_transcripts %>%
select(MAG, PredictedTrophicMode) %>% distinct() %>%
column_to_rownames(var = "MAG")
rownames(annot_mag) <- rownames(vita_only)
unique(annot_mag$PredictedTrophicMode)## [1] "Phototroph" "Heterotroph"annot_color = list(PredictedTrophicMode = c(Phototroph = "#B4CC3D", Heterotroph = "#CC3D6D"))# svg("heatmap-26-KOs.svg", h = 15, w = 16)
pheatmap(targetgene_26_byMAG,
annotation_row = annot_mag,
annotation_colors = annot_color,
annotation_names_row = FALSE,
scale = "column",
cluster_cols = TRUE,
cluster_rows = TRUE,
clustering_distance_rows = "euclidean",
clustering_distance_cols = "euclidean",
show_colnames = TRUE)
# dev.off()
# ?pheatmap()Generate p/a table
p_a_table <- subset_mapped_transcripts %>%
filter(KO %in% kegg_set) %>%
select(MAG, KO, SUM) %>% distinct() %>%
mutate(bin = case_when(
SUM > 0 ~ 1,
SUM == 0 ~ -1
)) %>%
pivot_wider(id_cols = MAG, names_from = KO,
values_from = bin, values_fill = -1)
# dim(p_a_table)
# write_delim(p_a_table, path = "subset-keggIDs-stramenopileMAGs-27-04-2021.txt", delim = "\t")
gene_set_list <- subset_mapped_transcripts %>%
filter(KO %in% kegg_set) %>% select(Annotation, KO) %>% distinct()
# View(gene_set_list)